| Myocardial and haemodynamic effects of phentolamine. | |
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MedLine Citation:
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PMID: 4396969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. In cats anaesthetized with pentobarbitone, intravenous infusions of phentolamine ((10-50 mug/kg)/min for 5 min) increased heart rate, left ventricular dp/dt max (without increasing end-diastolic pressure), aortic dp/dt, cardiac output, myocardial blood flow and metabolic heat production.2. Phentolamine-induced increases in myocardial contractility occurred irrespective of the direction or magnitude of the blood pressure change and were maintained well beyond the actual infusion period.3. In cats treated with alprenolol, bretylium or reserpine there was no evidence of increased cardiac contractility following phentolamine administration.4. It is concluded that phentolamine, in doses less than those required to produce significant alpha-adrenoceptor blockade, increased myocardial contractility through an effect on the sympathetic nervous system. |
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Authors:
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P K Das; J R Parratt |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of pharmacology Volume: 41 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1971 Mar |
Date Detail:
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Created Date: 1971-07-06 Completed Date: 1971-07-06 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 437-44 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology Amino Alcohols / pharmacology Animals Blood Flow Velocity Blood Pressure / drug effects Body Temperature Regulation / drug effects Bretylium Compounds / pharmacology Cardiac Output / drug effects Cats Female Heart / drug effects* Heart Rate / drug effects Hemodynamics / drug effects* Male Muscle Contraction / drug effects Phentolamine / antagonists & inhibitors, pharmacology* Reserpine / pharmacology Sympathetic Nervous System / drug effects Sympatholytics / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Amino Alcohols; 0/Bretylium Compounds; 0/Sympatholytics; 50-55-5/Reserpine; 50-60-2/Phentolamine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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