Document Detail

Myocardial and haemodynamic effects of phentolamine.
MedLine Citation:
PMID:  4396969     Owner:  NLM     Status:  MEDLINE    
1. In cats anaesthetized with pentobarbitone, intravenous infusions of phentolamine ((10-50 mug/kg)/min for 5 min) increased heart rate, left ventricular dp/dt max (without increasing end-diastolic pressure), aortic dp/dt, cardiac output, myocardial blood flow and metabolic heat production.2. Phentolamine-induced increases in myocardial contractility occurred irrespective of the direction or magnitude of the blood pressure change and were maintained well beyond the actual infusion period.3. In cats treated with alprenolol, bretylium or reserpine there was no evidence of increased cardiac contractility following phentolamine administration.4. It is concluded that phentolamine, in doses less than those required to produce significant alpha-adrenoceptor blockade, increased myocardial contractility through an effect on the sympathetic nervous system.
P K Das; J R Parratt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  41     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1971 Mar 
Date Detail:
Created Date:  1971-07-06     Completed Date:  1971-07-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  437-44     Citation Subset:  IM    
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology
Amino Alcohols / pharmacology
Blood Flow Velocity
Blood Pressure / drug effects
Body Temperature Regulation / drug effects
Bretylium Compounds / pharmacology
Cardiac Output / drug effects
Heart / drug effects*
Heart Rate / drug effects
Hemodynamics / drug effects*
Muscle Contraction / drug effects
Phentolamine / antagonists & inhibitors,  pharmacology*
Reserpine / pharmacology
Sympathetic Nervous System / drug effects
Sympatholytics / pharmacology
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Amino Alcohols; 0/Bretylium Compounds; 0/Sympatholytics; 50-55-5/Reserpine; 50-60-2/Phentolamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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