Document Detail


Myocardial gene transfer.
MedLine Citation:
PMID:  11139797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent improvements in both gene transfer vectors and in vivo gene delivery techniques have facilitated genetic manipulation of myocardial function and enabled targeted therapy of animal models of cardiac disease and, in particular, heart failure. Increases in myocardial perfusion, improved calcium handling, and enhanced beta-adrenergic receptor signaling have all been achieved by gene transfer in animal models, and appear to be important determinants of myocardial function. Increased understanding of the molecular etiologies of myocardial disease processes combined with advances in vectors and gene delivery will facilitate the development of novel therapies and represent important progress in the effort to make myocardial gene therapy a clinical reality beyond experimental protocols.
Authors:
D C White; W J Koch
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current cardiology reports     Volume:  3     ISSN:  1523-3782     ISO Abbreviation:  Curr Cardiol Rep     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-06-07     Revised Date:  2006-04-21    
Medline Journal Info:
Nlm Unique ID:  100888969     Medline TA:  Curr Cardiol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  37-42     Citation Subset:  IM    
Affiliation:
Department of Surgery, Box 2606, MSRB Room 471, Duke University Medical Center, Durham, NC 27710, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcium / metabolism
Endothelial Growth Factors / therapeutic use
Gene Transfer Techniques*
Genetic Vectors
Heart Diseases / therapy*
Humans
Lymphokines / therapeutic use
Myocardial Contraction / physiology
Myocardium* / metabolism
Transfection
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Chemical
Reg. No./Substance:
0/Endothelial Growth Factors; 0/Lymphokines; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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