Document Detail

Myocardial function in infarcted and remote regions early after infarction in man: assessment by magnetic resonance tagging and strain analysis.
MedLine Citation:
PMID:  9358455     Owner:  NLM     Status:  MEDLINE    
Early after infarction in the perfusion bed of the left anterior descending coronary artery, cine MRI with spatial modulation of magnetization (SPAMM) tagging (7-mm grid) was used for short- and long-axis cardiac imaging. Two-dimensional strain analysis of triangular finite elements was performed between end-diastole and end-systole. Patients (n = 10) were compared with age-matched healthy subjects (n = 8). The anteroseptal region at midventricular level was considered representative for "infarcted" and the posterolateral region at basal level was considered "remote". The left ventricular end-diastolic volume index was larger in the patients (69 +/- 15 ml/m2 versus 56 +/- 4 ml/m2, P < 0.05). Short-axis images showed in the infarcted region a decrease of first principal strain (greatest systolic lengthening: 1.10 +/- .06 versus 1.27 +/- 0.04, P < 0.0001), and in the remote region an increase (1.48 +/- 0.11 versus 1.36 +/- 0.07, P < 0.025). The lateral and inferior ventricular regions at mid- and basal levels were found to function normally. Long-axis images yielded similar results. Early after infarction, regions with dysfunction, normal function, and hyperfunction can be delineated with MR tagging. The compensatory increased contraction in the remote region is possibly triggered by the Frank-Starling mechanism.
J T Marcus; M J Götte; A C Van Rossum; J P Kuijer; R M Heethaar; L Axel; C A Visser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  38     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-12-16     Completed Date:  1997-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  803-10     Citation Subset:  IM    
Department of Medical Physics and Informatics, Institute for Cardiovascular Research ICaR-VU, Vrije Universiteit, Amsterdam, The Netherlands.
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MeSH Terms
Case-Control Studies
Magnetic Resonance Imaging, Cine / methods*
Middle Aged
Myocardial Contraction / physiology
Myocardial Infarction / pathology*,  physiopathology
Time Factors

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