Document Detail

Myocardial function in children and adolescents after therapy with anthracyclines and chest irradiation.
MedLine Citation:
PMID:  8695252     Owner:  NLM     Status:  MEDLINE    
Cardiotoxicity is a potential adverse effect of anthracycline (A) therapy. Radiotherapy (XRT) may also cause a variety of cardiac complications. The purpose of the present study was to evaluate these cardiac side-effects in children and adolescents treated for cancer. We assessed the cardiac status of 91 patients, divided into three groups: Group A (n = 53) had anthracyclines at a mean cumulative dose of 410 mg/m2, group A+XRT (n = 26) had both chest irradiation (XRT) and A (mean 360 mg/m2), and group XRT (n = 12) had XRT alone. The patients differed from the controls in both systolic and diastolic indices of myocardial function. In echocardiography, the left ventricular (LV) contractility was abnormal in 32% in group A, in 50% in group A+XRT, and in 8% in group XRT. In radionuclide cineangiography, the LV ejection fraction was subnormal in 19% in group A, in 24% in group A+XRT, and in 1 patient in group XRT. A higher cumulative dose of A predicted decreased contractility. Treatment with A and/or XRT often leads to cardiotoxicity. Although in most cases this cardiotoxicity seems to be mild and subclinical, the long-term clinical sequelae merit further evaluation.
J Pihkala; U M Saarinen; U Lundström; K Virtanen; K Virkola; M A Siimes; E Pesonen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  32A     ISSN:  0959-8049     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-09-05     Completed Date:  1996-09-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  97-103     Citation Subset:  IM    
Children's Hospital, University of Helsinki, Finland.
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MeSH Terms
Antibiotics, Antineoplastic / adverse effects*
Child, Preschool
Combined Modality Therapy
Daunorubicin / adverse effects
Doxorubicin / adverse effects
Follow-Up Studies
Heart / physiopathology
Heart Diseases / chemically induced,  diagnosis,  etiology*
Neoplasms / therapy*
Radiation Injuries / etiology*
Radiotherapy / adverse effects
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 20830-81-3/Daunorubicin; 23214-92-8/Doxorubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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