| Myocardial function and energy metabolism in carnitine-deficient rats. | |
| | |
MedLine Citation:
|
PMID: 12785723 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Carnitine is essential for mitochondrial metabolism of long-chain fatty acids and thus for myocardial energy production. Accordingly, carnitine deficiency can be associated with cardiomyopathy. To better understand this disease, we determined myocardial function and energy metabolism in a rat model of carnitine deficiency. Carnitine deficiency was induced by a 3- or 6-week diet containing N-trimethyl-hydrazine-3-propionate, reducing cardiac and plasma carnitine by 70-85%. Myocardial function was investigated in isolated isovolumic heart preparations. Carnitine-deficient hearts showed left ventricular systolic dysfunction, reduced contractile reserve, and a blunted frequency-force relationship independently of the substrate used (glucose or palmitate). After glycogen depletion, palmitate could not sustain myocardial function. Histology and activities of carnitine palmitoyl transferase, citrate synthase, and cytochrome c oxidase were unaltered. Thus, as little as 3-6 weeks of systemic carnitine deficiency can lead to abnormalities in myocardial function. These abnormalities are masked by endogenous glycogen and are not accompanied by structural alterations of the myocardium or by altered activities of important mitochondrial enzymes. |
| | |
Authors:
|
C E Zaugg; M Spaniol; P Kaufmann; M Bellahcene; V Barbosa; M Tolnay; P T Buser; S Krähenbühl |
Related Documents
:
|
23085673 - Predictive value of brachial-ankle pulse wave velocity for cardiovascular events. 17652893 - Inhibition of endogenous nitric oxide synthase augments contractile response to adenyly... 15005213 - Mechanisms of atrial fibrillation. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Cellular and molecular life sciences : CMLS Volume: 60 ISSN: 1420-682X ISO Abbreviation: Cell. Mol. Life Sci. Publication Date: 2003 Apr |
Date Detail:
|
Created Date: 2003-06-05 Completed Date: 2003-06-25 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9705402 Medline TA: Cell Mol Life Sci Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 767-75 Citation Subset: IM |
Affiliation:
|
Department of Research, University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland. Christian.Zaugg@unibas.ch |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine Triphosphate
/
metabolism Animals Carnitine / blood, deficiency*, metabolism Glycogen / deficiency, metabolism Heart / physiology* Mitochondria / enzymology Myocardium / cytology Phosphocreatine / metabolism Rats |
| Chemical | |
Reg. No./Substance:
|
541-15-1/Carnitine; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine; 9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mast cells stimulated by membrane-bound, but not soluble, steel factor are dependent on phospholipas...
Next Document: Sphingosine 1-phosphate antagonizes human neutrophil apoptosis via p38 mitogen-activated protein kin...