| Myocardial fluid balance in acute hypertension. | |
| | |
MedLine Citation:
|
PMID: 9086448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: We hypothesized that (1) acute arterial hypertension increases myocardial microvascular fluid filtration and (2) the combination of acute arterial hypertension and coronary sinus pressure elevation may increase myocardial microvascular filtration sufficiently to estimate the osmotic reflection coefficient of the myocardial exchange vessels. METHODS: In nine mechanically ventilated dogs we cannulated the prenodal major cardiac lymph trunk. With the use of central venous phenylephrine infusion, mean arterial pressure (MAP) was raised progressively to 120, 160, and 180 mm Hg. In five dogs we additionally raised coronary sinus pressure (CSP) to 20 and 40 mm Hg. At each manipulation of MAP and/or CSP, we measured indexes of myocardial lymphatic function and lymph-to-plasma concentration ratios for total protein (CL(TP)/CP(TP) and albumin (CL(alb)/CP(alb)). RESULTS: Myocardial lymph flow rate (QL; microL/min) increased exponentially (QL = 10.9.e0.014.(MAP) and myocardial lymph driving pressure (PL; mm Hg) increased linearly (PL = 2.30 + 0.20 + 0.20 . MAP) following increases, whereas CL(TP)/CP(TP) and CL(alb)/CP(alb) decreases from 0.67 +/- 0.07 (SD) to 0.56 +/- 0.10 and from 0.91 +/- 0.05 to 0.75 +/- 0.11, respectively. Adding CSP elevation increased QL up to 12 times control associated with further CL(TP)/C(TP) and CL(alb)/CP(alb) decreases to 0.49 +/- 0.05 and 0.59 +/- 0.02, respectively. CONCLUSIONS: We conclude that hypertensive arterial pressures are, at least in part, transmitted to the myocardial microvascular exchange vessels in the intact animal leading to increased microvascular fluid filtration. However, the combination of acute arterial hypertension and coronary sinus pressure elevation is not sufficient to produce filtration independence required for myocardial osmotic reflection coefficient determination. |
| | |
Authors:
|
U Mehlhorn; K L Davis; G A Laine; H J Geissler; S J Allen |
Related Documents
:
|
8693428 - Actions of acute ethanol intoxication on cardiopulmonary function after an endotoxin ch... 16481948 - Prophylactic cephazolin to prevent discitis in an ovine model. 9817688 - Inhaled nitric oxide reduces lung fluid filtration after endotoxin in awake sheep. 10600918 - Relationship between intracranial pressure and cervical lymphatic pressure and flow rat... 8773158 - Conversions from captopril to lisinopril at a dosage ratio of 5:1 result in comparable ... 22650318 - Theoretical study of the thermal decomposition of 5-methyl-2-furanylmethyl radical. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Microcirculation (New York, N.Y. : 1994) Volume: 3 ISSN: 1073-9688 ISO Abbreviation: Microcirculation Publication Date: 1996 Dec |
Date Detail:
|
Created Date: 1997-06-26 Completed Date: 1997-06-26 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9434935 Medline TA: Microcirculation Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 371-8 Citation Subset: IM |
Affiliation:
|
Department of Anesthesiology, University of Texas Medical School, Houston 77030, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects Catheterization Coronary Vessels / physiopathology* Dogs Edema Heart / physiopathology* Hemodynamics Hypertension / physiopathology* Lymph / physiology Male Microcirculation / physiology Phenylephrine / pharmacology Water-Electrolyte Balance / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
HL-36115/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
59-42-7/Phenylephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cytokeratin expression and hyaluronic acid production in cultures of human synovial microvascular en...
Next Document: Induction of cyclooxygenase-2 following anoxic stress in piglet cerebral arteries.