Document Detail

Myocardial fatty acid imaging identifies a group of hemodialysis patients at high risk for cardiac death after coronary revascularization.
MedLine Citation:
PMID:  18528325     Owner:  NLM     Status:  MEDLINE    
We prospectively evaluated if impaired myocardial fatty acid metabolism is involved in cardiac death after revascularization by percutaneous coronary artery intervention in dialysis patients. A cohort of hemodialysis patients was assessed by dual single-photon emission computed tomography using the radioiodinated fatty acid analogue BMIPP and radiolabeled thallium chloride. Tomography was done within one month before the first coronary intervention and at the last follow-up angiography at which neither restenosis nor de novo lesions were detected. Radiolabel uptake on tomography images was graded in segments and calculated as summed BMIPP or thallium scores. Among the 90 hemodialysis patients in the study, 19 died of cardiac events. Multivariate Cox hazard analysis found a significant association of cardiac death with the BMIPP summed scores at the last follow-up angiography. Kaplan-Meier analysis showed the cardiac death-free survival rates at 3 years of follow-up were significantly higher in patients with lower BMIPP summed scores. These results suggest that myocardial fatty acid imaging may be a useful test to identify high risk groups of cardiac death in hemodialysis patients.
Masato Nishimura; Toshiko Tokoro; Masasya Nishida; Tetsuya Hashimoto; Hiroyuki Kobayashi; Satoru Yamazaki; Ryo Imai; Koji Okino; Hakuo Takahashi; Toshihiko Ono
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Publication Detail:
Type:  Journal Article     Date:  2008-06-04
Journal Detail:
Title:  Kidney international     Volume:  74     ISSN:  1523-1755     ISO Abbreviation:  Kidney Int.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-01     Completed Date:  2008-11-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  513-20     Citation Subset:  IM    
Cardiovascular Division, Toujinkai Hospital, Kyoto, Japan.
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MeSH Terms
Cohort Studies
Coronary Angiography
Coronary Artery Disease / complications,  pathology,  radionuclide imaging*
Death, Sudden, Cardiac*
Fatty Acids / diagnostic use*
Iodine Radioisotopes / diagnostic use
Iodobenzenes / diagnostic use*
Middle Aged
Myocardium / metabolism
Predictive Value of Tests
Prospective Studies
ROC Curve
Renal Dialysis*
Risk Assessment
Thallium Radioisotopes / diagnostic use
Tomography, Emission-Computed, Single-Photon*
Reg. No./Substance:
0/Fatty Acids; 0/Iodine Radioisotopes; 0/Iodobenzenes; 0/Thallium Radioisotopes; 116754-87-1/iodofiltic acid

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