| Myocardial failure. | |
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MedLine Citation:
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PMID: 7064058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The majority of evidence suggests that there is myocardial dysfunction resulting from sepsis. Clinical observations seem to suggest that the dysfunction is not on the basis of decreased venous return of increased afterload. Reduced myocardial compliance and isolated right ventricular failure also do not account for what is seen clinically. The explanation appears to be decreased myocardial contractility. Several factors may be responsible for reducing contractility, including altered response to catecholamines; metabolic acidosis; altered distribution of blood flow within the myocardial wall resulting in hypoxic regions; the elaboration of substances that act directly to reduce contractility, including intestinal shock factors and endorphins; and alterations of excitation-contraction coupling resulting from changes in calcium concentrations or reduced responsiveness to the calcium ion. Further work is needed to determine which of these factors predominate. |
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Authors:
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M Levison |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Surgical clinics of North America Volume: 62 ISSN: 0039-6109 ISO Abbreviation: Surg. Clin. North Am. Publication Date: 1982 Feb |
Date Detail:
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Created Date: 1982-05-21 Completed Date: 1982-05-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0074243 Medline TA: Surg Clin North Am Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 149-56 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / complications Anti-Arrhythmia Agents / physiology Calcium / blood Cardiac Output Catecholamines / blood Dogs Heart Arrest / etiology*, physiopathology Heart Ventricles / physiopathology Humans Myocardial Contraction Shock, Septic / complications*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Catecholamines; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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