Document Detail

Myocardial extraction of cyclic AMP during pacing-induced angina.
MedLine Citation:
PMID:  224857     Owner:  NLM     Status:  MEDLINE    
The application of cyclic AMP as a marker of myocardial ischemia in humans with coronary artery disease has been investigated during pacing-induced angina. Cyclic AMP was determined by a radioimmunoassay. In 15 patients myocardial lactate extraction at rest (20 +/- 12%) converted to production levels (-30 +/- 23%) during angina (p less than 0.0005). Insignificant changes occurred in coronary venous plasma cyclic-AMP levels. The mean myocardial cyclic-AMP extraction at rest (0.3 +/- 8.7%) converted to small release values (-6.0 +/-11%) during angina (= n.s.). No significant correlation was found between myocardial lactate and cyclic-AMP uptake or release. Therefore, cyclic AMP is an insensitive marker in the evaluation of myocardial ischemia.
G Kugler; S Nolde
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Basic research in cardiology     Volume:  74     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:    1979 Mar-Apr
Date Detail:
Created Date:  1979-10-17     Completed Date:  1979-10-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  155-60     Citation Subset:  IM    
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MeSH Terms
Angina Pectoris / etiology*
Cyclic AMP / biosynthesis,  metabolism*
Heart Rate
Lactates / blood
Myocardium / metabolism*
Physical Exertion*
Reg. No./Substance:
0/Lactates; 60-92-4/Cyclic AMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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