Document Detail


Myocardial extra-cellular matrix and its regulation by metalloproteinases and their inhibitors.
MedLine Citation:
PMID:  15711735     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiovascular disease poses a major health care burden in the Western world. Following myocardial injuries, ventricular remodelling and dysfunction ensue, which can eventually culminate in heart failure. An important event in left ventricular (LV) remodelling is alteration of the extracellular matrix (ECM) integrity, the structural network that interconnects the myocardial components. The critical role of ECM remodelling in cardiac dilation and heart failure was recognized more than a decade ago, and the molecular factors responsible for this process are now being explored. Abnormal ECM turnover is primarily brought about by an imbalance in the activity of matrix metalloproteinases (MMPs) that degrade ECM components, and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). Here we provide an overview of composition of the cardiac ECM, and alterations in ECM regulatory proteins, MMPs and TIMPs, in human heart disease. We also discuss the role of TIMPs, MMPs, and a disintegrin and metalloproteinase (ADAMs) enzymes in cardiac development and function as learned through genetically altered mouse models.
Authors:
Zamaneh Kassiri; Rama Khokha
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  93     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-15     Completed Date:  2005-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  212-9     Citation Subset:  IM    
Affiliation:
Ontario Cancer Institute, University of Toronto, University Health Network, Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Extracellular Matrix / metabolism*
Heart / growth & development
Heart Diseases / enzymology,  pathology
Humans
Metalloproteases / antagonists & inhibitors,  physiology*
Mice
Myocardium / cytology,  enzymology,  ultrastructure*
Tissue Inhibitor of Metalloproteinases
Chemical
Reg. No./Substance:
0/Tissue Inhibitor of Metalloproteinases; EC 3.4.-/Metalloproteases
Comments/Corrections
Comment In:
Thromb Haemost. 2005 Feb;93(2):190-1   [PMID:  15711731 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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