| Myocardial "equilibration processes" and myocardial energy turnover during initiation of artificial cardiac arrest with cardioplegic solution - reasons for a sufficiently long cardioplegic perfusion. | |
| | |
MedLine Citation:
|
PMID: 6166077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In canine hearts the myocardial equilibration processes (temperature, pO2, pCO2, Na+, K+) and the myocardial energy turnover were analyzed at the beginning of a cardioplegically induced cardiac arrest during a coronary perfusion of 10 minutes. The investigated hearts (n = 10) were perfused with the Bretschneider histidine-buffered cardioplegic solution according to the recommendations worked out for clinical use. The results show that during the cardioplegic coronary perfusion of 10 minutes the cooling and temperature equilibration of the myocardium occur considerably faster than the establishment of a new energy steady-state at a very low level. The minimalization of the coronary resistance and of the myocardial O2 consumption are only reached after an extended perfusion period of 7 to 9 minutes. In consequence of the results, the following recommendations can be given for the clinical use of the Bretschneider cardioplegic solution: a) the solution should be used at a temperature of between 5 degrees and 10 degrees C, b) the cardioplegic coronary flow should be between 60 and 80 ml/min . 100 gww, c) the human heart should be perfused for 8 to 10 minutes and, d) the perfusion pressure should be maintained at 40 to 50 mmHg after cardiac arrest has set in. So far the action of equilibration procedures when using the Bretschneider cardioplegic method has not been compared with that of other cardioplegic methods. |
| | |
Authors:
|
C J Preusse; M M Gebhard; H J Bretschneider |
Related Documents
:
|
8896157 - Effect of phosphodiesterase iii-inhibitor (e-1020) adjunct to bretschneider's htk cardi... 511907 - Improving results in combined aortic and mitral valve replacement using cold potassium ... 8572787 - Comparisons of methods of myocardial hypothermia for cardiac transplantation. 15797737 - Na+/h+ exchange inhibition and antioxidants lack additive protective effects after repe... 21266917 - Vernakalant selectively prolongs atrial refractoriness with no effect on ventricular re... 8425297 - Augmentation of coronary blood flow by intra-aortic balloon pumping in patients after c... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Thoracic and cardiovascular surgeon Volume: 29 ISSN: 0171-6425 ISO Abbreviation: Thorac Cardiovasc Surg Publication Date: 1981 Apr |
Date Detail:
|
Created Date: 1981-08-27 Completed Date: 1981-08-27 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7903387 Medline TA: Thorac Cardiovasc Surg Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 71-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aorta / physiopathology Body Temperature Carbon Dioxide / blood Coronary Circulation Coronary Vessels Dogs Energy Metabolism* Esophagus / physiopathology Female Heart Arrest, Induced* Heart Rate Male Myocardium / metabolism* Oxygen / blood Oxygen Consumption Perfusion Pressure Veins |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intrapleural instillation of streptokinase. Effects on systemic fibrinolysis.
Next Document: Surgical constriction of the pulmonary artery. A new experimental technique.