| Myocardial emission computed tomography with iodine-123-labeled beta-methyl-branched fatty acid in patients with hypertrophic cardiomyopathy. | |
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MedLine Citation:
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PMID: 1530969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied whether emission computed tomography (ECT) with 123I-labeled 15-(p-iodophenyl)-3R,S-methylpentadecanoic acid (BMIPP) shows myocardial distribution different from 201Tl in hypertrophic cardiomyopathy. In 10 patients with asymmetric septal hypertrophy (ASH), 5 with diffuse hypertrophy and 2 with apical hypertrophy, ECT was acquired 30 min (early) and 4 hr (late) after injection of 123I-BMIPP at rest and was compared with ECT with 201Tl. In 10 patients with ASH, the relative regional uptake (RRU) of the septum was lower in the early 123I-BMIPP study than in the 201Tl study, although that of the posterior wall was similar. In the early and late 123I-BMIPP studies, the RRU of the septum was lower in 10 patients with ASH than in 7 without ASH, although that of the posterior wall was similar. In the 201Tl study, however, the RRU of both the septum and posterior wall was similar in those with and without ASH. Moreover, in 16 patients, the apparent left ventricular size was larger in the early 123I-BMIPP study than in the 201Tl study, which suggested reduced 123I-BMIPP uptake in the subendocardium. In patients with hypertrophic cardiomyopathy, thus, 123I-BMIPP imaging may reveal impaired regional fatty acid utilization, which is independent of regional perfusion. |
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Authors:
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C Kurata; K Tawarahara; T Taguchi; S Aoshima; A Kobayashi; N Yamazaki; H Kawai; M Kaneko |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 33 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1992 Jan |
Date Detail:
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Created Date: 1992-02-18 Completed Date: 1992-02-18 Revised Date: 2006-05-06 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 6-13 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, Hamamatsu University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiomegaly / radionuclide imaging* Cardiomyopathy, Hypertrophic / radionuclide imaging* Fatty Acids* Female Heart Septum / radionuclide imaging Humans Iodine Radioisotopes / diagnostic use* Iodobenzenes / diagnostic use* Male Middle Aged Thallium / diagnostic use Tomography, Emission-Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Iodine Radioisotopes; 0/Iodobenzenes; 116754-87-1/iodofiltic acid; 7440-28-0/Thallium |
| Comments/Corrections | |
Comment In:
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J Nucl Med. 1992 Oct;33(10):1914
[PMID:
1290514
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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