Document Detail

Myocardial dysfunction in silent myocardial ischemia as demonstrated by ambulatory radionuclide left ventricular function studies.
MedLine Citation:
PMID:  1504978     Owner:  NLM     Status:  MEDLINE    
Until recently, it has not been possible to combine both ambulatory electrocardiographic monitoring, monitoring and ambulatory left ventricular function monitoring, but new developments have helped solve this problem. A technique based on the nuclear probe was introduced in the early 1980s to allow continuous recording of left ventricular volumes and ejection fraction over a 4 to 6 hour period during ambulatory activities following a single injection of radioisotope; the device was termed the VEST. In addition to validation studies, left ventricular function during ambulatory activities of various types has been measured with the VEST, and there are now several reports that document reduction in left ventricular ejection fraction in patients with coronary artery disease. These episodes meet the criteria for silent ischemia: objective evidence of myocardial ischemia in the absence of angina or anginal equivalents. Thus, patients with coronary artery disease can be followed for hemodynamic evidence of myocardial ischemia (even when they are not aware of the episodes) and results of therapy better monitored than by the ambulatory ECG alone.
P F Cohn
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiology clinics     Volume:  10     ISSN:  0733-8651     ISO Abbreviation:  Cardiol Clin     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-09-21     Completed Date:  1992-09-21     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8300331     Medline TA:  Cardiol Clin     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  473-8     Citation Subset:  IM    
Department of Medicine, State University of New York Health Sciences Center, Stony Brook.
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MeSH Terms
Coronary Disease / physiopathology*,  radionuclide imaging*
Electrocardiography, Ambulatory / instrumentation,  methods
Gated Blood-Pool Imaging / instrumentation,  methods*
Monitoring, Physiologic / instrumentation,  methods

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