Document Detail


Myocardial dysfunction in septic shock.
MedLine Citation:
PMID:  2981522     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myocardial depression is a major but poorly understood component of septic shock. This study investigates the morphologic and biochemical abnormalities associated with septic shock. Myocardial cells are incubated in normal and septic plasma in a nutrient-, oxygen-, pH-, electrolyte-, and temperature-controlled environment. Cells and media are tested for basal- and epinephrine-stimulated cyclic adenosine monophosphate (cAMP), lactic dehydrogenase (LDH), and creatine kinase. Electron microscopic studies are done at the end of incubation. Septic LDH and creatine kinase levels in the media are increased substantially, and septic cAMP levels are reduced significantly. Septic cells beat irregularly and arrest along with exhibiting abnormal electron microscopic structure. Septic myocardial dysfunction occurs independently of previously postulated causes that are controlled for in this experiment and therefore may be due to endogenously produced or accumulated toxic factor(s).
Authors:
R H Carmona; T Tsao; M Dae; D D Trunkey
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of surgery (Chicago, Ill. : 1960)     Volume:  120     ISSN:  0004-0010     ISO Abbreviation:  Arch Surg     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-02-07     Completed Date:  1985-02-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9716528     Medline TA:  Arch Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  30-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Creatine Kinase / metabolism
Culture Media
Cyclic AMP / metabolism
Epinephrine / pharmacology
Heart / physiopathology*
L-Lactate Dehydrogenase / metabolism
Myocardial Contraction
Myocardium / metabolism*,  ultrastructure
Rats
Shock, Septic / metabolism,  physiopathology*
Stimulation, Chemical
Chemical
Reg. No./Substance:
0/Culture Media; 51-43-4/Epinephrine; 60-92-4/Cyclic AMP; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.7.3.2/Creatine Kinase

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