Document Detail

Myocardial dysfunction in sepsis.
MedLine Citation:
PMID:  2647229     Owner:  NLM     Status:  MEDLINE    
The characteristic hemodynamic profile of human septic shock consists of a normal or elevated cardiac index and a decreased systemic vascular resistance index. When a patient with septic shock has a low cardiac index, concomitant hypovolemia is usually present. Within 48 hours of the onset of septic shock, most patients develop marked dilatation of both ventricles, depressed ejection fractions, and alterations of the Frank-Starling and diastolic pressure-volume relationships; stroke volume typically is well maintained. In surviving patients, cardiac function returns to normal within 10 days. An identical sequence of hemodynamic abnormalities occurs in an experimental canine model of sepsis that employs intraperitoneal implantation of infected fibrin clots. This myocardial dysfunction is not due to global myocardial ischemia; instead, there appear to be one or more circulating myocardial depressant substances. The chemical nature of these circulation mediators is under intensive investigation clinically, in vitro, and in the canine model.
R E Cunnion; J E Parrillo
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Critical care clinics     Volume:  5     ISSN:  0749-0704     ISO Abbreviation:  Crit Care Clin     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-05-05     Completed Date:  1989-05-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8507720     Medline TA:  Crit Care Clin     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  99-118     Citation Subset:  IM    
Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland.
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MeSH Terms
Disease Models, Animal
Heart / physiopathology*
Shock, Septic / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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