| Myocardial dysfunction after electrical defibrillation. | |
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MedLine Citation:
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PMID: 12204463 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We hypothesized that electrical shocks that defibrillate hearts successfully also produce myocardial injury, but only in settings in which the myocardium is underperfused. Myocardial function was measured in isolated, conventionally perfused or underperfused rat hearts during sinus rhythm and conventionally perfused or underperfused hearts during ventricular fibrillation (VF) after delivery of a sham, a 0.4 J, or a 0.7 J shock. In underperfused hearts, the dP/dt, negative dP/dt, left ventricular diastolic pressure and left ventricular pressure-volume relationships demonstrated significant impairment in myocardial function. Impairment increased with the higher energy shocks. This contrasted with normally perfused hearts, whether in sinus rhythm or during VF, in which shocks resulted in no significant impairment. Electrical shocks therefore produce myocardial injury but only when myocardial perfusion is reduced. |
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Authors:
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Hitoshi Yamaguchi; Max Weil; Wanchun Tang; Takashi Kamohara; Xiaohua Jin; Joe Bisera |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Resuscitation Volume: 54 ISSN: 0300-9572 ISO Abbreviation: Resuscitation Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-09-02 Completed Date: 2003-04-01 Revised Date: 2009-08-25 |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: Ireland |
Other Details:
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Languages: eng Pagination: 289-96 Citation Subset: IM |
Affiliation:
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Institute of Critical Care Medicine, 1695 North Sunrise Way, Building #3, 92262, Palm Springs, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiomyopathies / etiology* Coronary Circulation / physiology Electric Countershock / adverse effects*, methods Rats Rats, Sprague-Dawley Ventricular Fibrillation / complications |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL54322/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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