Document Detail

Myocardial distribution of indium-111-antimyosin Fab in acute inferior and right ventricular infarction: comparison with technetium-99m-pyrophosphate imaging and histologic examination.
MedLine Citation:
PMID:  1850785     Owner:  NLM     Status:  MEDLINE    
In a postmortem study of a 69-yr-old female patient who had suffered 2 yr previously a non-Q-wave anterior infarction and who had sustained just seven days earlier a left inferior and right ventricular infarction, the distribution of 111In-antimyosin Fab was compared to the results of 99mTc-pyrophosphate imaging and histologic examination. Indium-111-antimyosin Fab imaging could not be performed because of cardiogenic shock. However, postmortem gamma scintillation counting revealed increased activities of antimyosin Fab in the inferoapical and right ventricular infarcted regions in which 99mTc-pyrophosphate positive imagings were observed; in contrast, a histologically confirmed old subendocardial anterior infarction had no definite activity. Thus, the myocardial distribution of 111In-antimyosin Fab corresponded well to the results of 99mTc scintigrams and histologic examinations in a human heart, suggesting that this technique could be useful in vivo for detecting several-day-old myocardial infarction of the right ventricle as well as the left ventricle. Tissue from the 2-yr-old infarction was not identified by this technique.
T Nakata; T Sakakibara; T Noto; T Shoji; T Tsuda; M Kubota; A Hattori; O Iimura
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  32     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-06-04     Completed Date:  1991-06-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  865-7     Citation Subset:  IM    
Second Department of Internal Medicine, Sapporo Medical College, Japan.
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MeSH Terms
Antibodies, Monoclonal / diagnostic use,  pharmacokinetics*
Diphosphates / diagnostic use*
Myocardial Infarction / metabolism*,  pathology,  radionuclide imaging
Myocardium / pathology*
Organometallic Compounds / diagnostic use,  pharmacokinetics*
Technetium / diagnostic use*
Technetium Tc 99m Pyrophosphate
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Diphosphates; 0/Organometallic Compounds; 0/Technetium Tc 99m Pyrophosphate; 138660-99-8/imciromab pentetate; 7440-26-8/Technetium
Comment In:
J Nucl Med. 1991 May;32(5):867-70   [PMID:  2022997 ]

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