Document Detail

Myocardial depression in sepsis.
MedLine Citation:
PMID:  366163     Owner:  NLM     Status:  MEDLINE    
Myocardial failure is uniformly fatal when associated with post-traumatic sepsis and multisystem failure. Controversy exists as to whether endotoxin has a direct effect on the myocardium. A nonanoxic isolated arterially perfused rabbit interventricular septum was used in this study to evaluate the effects of endotoxin, live E. coli, and endotoxin/septic shock plasma on myocardial function and ultrastructure. Purified E. coli endotoxin and live E. coli bacteria did not have a significant direct effect on rabbit cardiac muscle function or ultrastructure. Perfusion of the rabbit septum with plasma from rabbits exsanguinated following a 2-hour septic or endotoxin shock insult, however, caused significant (p less than 0.02) myocardial depression when compared with control septa perfused with normal rabbit plasma. Septa perfused with shock plasma demonstrated ultrastructural alterations of mitochondria that were not noted in control preparations.
J Raffa; D D Trunkey
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Journal of trauma     Volume:  18     ISSN:  0022-5282     ISO Abbreviation:  J Trauma     Publication Date:  1978 Sep 
Date Detail:
Created Date:  1979-03-13     Completed Date:  1979-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  617-22     Citation Subset:  AIM; IM    
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MeSH Terms
Endotoxins / pharmacology
Escherichia coli
Heart / physiopathology*
Heart Septum / drug effects,  ultrastructure
Shock, Septic / blood,  physiopathology*
Reg. No./Substance:

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