Document Detail

Myocardial depression by ketamine. Haemodynamic and metabolic observations in animals.
MedLine Citation:
PMID:  7246986     Owner:  NLM     Status:  MEDLINE    
This study investigated the effect of ketamine on myocardial function. In dogs the drug was infused directly into the left main coronary artery. The concentration chosen was similar to the peak concentration found following a bolus intravenous injection. A mild depression of inotropic state was found which recovered completely after stopping the infusion. Myocardial depression was confirmed in a guinea pig Langendorff preparation. No changes in high energy phosphates were found in these hearts after 45-60 minutes of perfusion with ketamine in the perfusion medium. This study confirms that myocardial depression occurs with ketamine but suggests that it is unlikely to be of clinical significance. Depletion of high energy phosphates did not seem to be the cause of the depression.
J H Chamberlain; R G Seed; N Undre
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anaesthesia     Volume:  36     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-08-10     Completed Date:  1981-08-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  366-70     Citation Subset:  AIM; IM    
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MeSH Terms
Adenosine Triphosphate / metabolism
Anesthesia, Intravenous
Depression, Chemical
Guinea Pigs
Hemodynamics / drug effects
Ketamine / pharmacology*
Myocardial Contraction / drug effects*
Myocardium / metabolism
Phosphocreatine / metabolism
Reg. No./Substance:
56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine; 6740-88-1/Ketamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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