| Myocardial degradation and left bundle branch block predict conversion to low ejection fraction in heart failure with preserved systolic function. | |
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MedLine Citation:
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PMID: 18772624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors prospectively investigated whether left bundle branch block (LBBB) and myocardial degradation as indicated by elevated troponin T (tnT) predict the phenomenon of systolic conversion to low ejection fraction (EF <or=40%) in patients with nonsignificant coronary disease and heart failure with preserved systolic function (HFPSF) (initial EF >40%). Thirty consecutive patients with HFPSF were included and followed over a 4-year interval. A follow-up EF assessment was performed in 25 patients. Six of 15 patients with tnT >or=0.01 ng/mL demonstrated systolic conversion to low EF on follow-up, while none of the 10 patients with tnT <0.01 ng/mL experienced this phenomenon (P=.03). Five of the 6 converters presented with LBBB, while only 1 of the 19 nonconverters had this abnormality (P=.0007). Four of the 6 converters had an initial EF >50%. Myocardial degradation and LBBB predicted systolic conversion in HFPSF patients with nonsignificant coronary disease. |
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Authors:
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George O Angheloiu; Mouyyad Rahaby; Randall C Starling; Viorel Angheloiu; Dennis M McNamara; Mohamad H Yamani; James B Young |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Congestive heart failure (Greenwich, Conn.) Volume: 14 ISSN: 1527-5299 ISO Abbreviation: Congest Heart Fail Publication Date: 2008 Jul-Aug |
Date Detail:
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Created Date: 2008-09-05 Completed Date: 2008-11-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9714174 Medline TA: Congest Heart Fail Country: United States |
Other Details:
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Languages: eng Pagination: 192-6 Citation Subset: IM |
Affiliation:
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Kaufman Center for Heart Failure, Department of Cardiovascular Diseases, Cleveland Clinic Foundation, Cleveland, OH, USA. angheloiu@pol.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Bundle-Branch Block / diagnosis, physiopathology* Disease Progression Female Heart Failure / diagnosis, physiopathology* Humans Male Middle Aged Myocardium / pathology* Prospective Studies Stroke Volume Systole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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