| Myocardial deformation abnormalities in patients with aortic regurgitation: a strain rate imaging study. | |
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MedLine Citation:
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PMID: 18579501 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Early left ventricular (LV) dysfunction in asymptomatic patients with severe aortic regurgitation (AR) may go undetected due to the lack of a sufficiently sensitive diagnostic tool. Ultrasonic strain/strain rate (S/SR) imaging should now provide such sensitivity in detecting early dysfunction in regional LV systolic deformation. The aim of this study was to understand and define the changes in LV regional systolic deformation based on S/SR imaging in patients with asymptomatic or minimally symptomatic AR. METHODS AND RESULTS: Eighty-one individuals were studied: 59 asymptomatic patients with isolated non-ischaemic AR who were divided into three sub-groups such as mild, moderate, and severe AR and 22 age-matched healthy subjects. All patients underwent standard echocardiographic examinations including a tissue Doppler imaging study. For LV radial deformation, the posterior wall (LVPW) was examined. To assess LV longitudinal deformation, S and SR data were acquired from the LV lateral wall and septum. Radial as well as longitudinal peak systolic SRs were significantly decreased in patients with both moderate AR (LVPW, P=0.0009; septum, P=0.03; LV lateral wall, P=0.0009) and severe AR (P<0.0001) compared with healthy subjects. Changes in regional LV deformation correlated inversely both with LV end-diastolic volume and with end-systolic volume. CONCLUSIONS: Strain rate imaging is a sensitive tool in detecting the spectrum of changes in radial and longitudinal deformation in asymptomatic or minimally symptomatic patients with AR. The index where volume was corrected by deformation should form the basis for predicting subclinical LV dysfunction in patients with increasing LV dilatation. |
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Authors:
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Anna Marciniak; George R Sutherland; Maciej Marciniak; Piet Claus; Bart Bijnens; Marjan Jahangiri |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-25 |
Journal Detail:
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Title: European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology Volume: 10 ISSN: 1532-2114 ISO Abbreviation: Eur J Echocardiogr Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-09 Completed Date: 2009-05-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890618 Medline TA: Eur J Echocardiogr Country: England |
Other Details:
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Languages: eng Pagination: 112-9 Citation Subset: IM |
Affiliation:
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Department of Cardiology and Cardiothoracic Surgery, St. George's Hospital, Blackshaw Road, London SW17 0QT, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aortic Valve Insufficiency / complications, ultrasonography* Case-Control Studies Chronic Disease Diagnostic Imaging / methods Echocardiography, Doppler, Color* Echocardiography, Doppler, Pulsed Female Follow-Up Studies Humans Male Middle Aged Myocardial Contraction / physiology Probability Risk Assessment Sensitivity and Specificity Severity of Illness Index Stroke Volume / physiology Ventricular Dysfunction, Left / complications, ultrasonography* Ventricular Remodeling / physiology |
| Grant Support | |
ID/Acronym/Agency:
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PG/06/009/20255//British Heart Foundation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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