Document Detail


Myocardial damage in successful single vessel coronary angioplasty as assessed by creatinine kinase and its myocardium band isoenzyme levels.
MedLine Citation:
PMID:  18460240     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the frequency of myocardial damage in elective, successful, single vessel percutaneous coronary angioplasty by assessing myocardial band (MB), creatinine kinase levels and to find out the association of common modifiable risk factors with myocardial damage in patients undergoing single vessel coronary angioplasty. STUDY DESIGN: Descriptive. PLACE AND DURATION OF STUDY: Armed Forces Institute of Cardiology / National Institute of Heart Disease, Rawalpindi, from September 2006 to September 2007. PATIENTS AND METHODS: Fifty patients undergoing elective and successful single vessel percutaneous coronary angioplasty were evaluated with creatinine kinase and creatinine kinase MB levels before and after 8 hours and 1st day following coronary angioplasty. Studied variables included the length of stent deployed, maximum deployment pressure and total balloon inflation time, apart from hypertension, cholesterol level, smoking and diabetes mellitus. RESULTS: Out of 50 patients, 9 had raised creatinine kinase at 8 hours (18%) and 10 had raised creatinine kinase (20%) on 1st day following coronary angioplasty, 7 (14%) patients and 8 (16%) patients had raised creatinine kinase MB levels at 8 hours and 1st day following coronary angioplasty respectively. The rise of either was equal to or more than 3 times the normal limits. Modifiable risk factors, significantly associated with myocardial damage, were diabetes mellitus (p=0.006) and LDL levels (p=0.009) in patients undergoing single vessel coronary angioplasty. CONCLUSION: Successful elective, uncomplicated, single vessel coronary angioplasty resulted in some myocardial damage evident by mild rise in cardiac enzymes but rise of creatinine kinase MB above 3 times of normal, which signifies percutaneous coronary angioplasty-related myocardial infarction, was not seen. There was a significant association between diabetes mellitus, LDL levels and myocardial damage in patients undergoing coronary angioplasty but no significant association was found between hypertension, smoking and myocardial damage.
Authors:
Shahid Abbas; Farhan Tayyab; Naseer Ahmed Samor; Muhammad Shabir; Azhar Mahmood Kayani
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the College of Physicians and Surgeons--Pakistan : JCPSP     Volume:  18     ISSN:  1022-386X     ISO Abbreviation:  J Coll Physicians Surg Pak     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-05-07     Completed Date:  2008-07-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606447     Medline TA:  J Coll Physicians Surg Pak     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  142-6     Citation Subset:  IM    
Affiliation:
Department of Adult Cardiology, Armed Forces Institute of Cardiology/National Institute of Health Diseases, Rawalpindi. shahabbas0@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Angioplasty, Transluminal, Percutaneous Coronary / adverse effects*
Biological Markers / analysis
Cardiomyopathies / diagnosis*,  etiology*
Cholesterol, LDL / blood
Creatine Kinase, MB Form / analysis*
Diabetes Mellitus
Female
Humans
Male
Middle Aged
Myocardium / enzymology*
Risk Factors
Stents / adverse effects*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cholesterol, LDL; EC 2.7.3.2/Creatine Kinase, MB Form

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