Document Detail

Myocardial contrast echocardiography in acute myocardial infarction. Pathophysiological background and clinical applications.
MedLine Citation:
PMID:  8737209     Owner:  NLM     Status:  MEDLINE    
Myocardial contrast echocardiography is a technique used in experimental and clinical settings in order to visualize the pattern of intramyocardial perfusion. In the acute phase of myocardial infarction, regional absence of flow during myocardial contrast echocardiography delineates the area at risk of necrosis, while the definitive non-perfused area expresses infarct size. Reopening the infarct-related artery, which may be achieved spontaneously by thrombolysis or percutaneous transluminal coronary angioplasty, is not a reliable indicator of intramyocardial reperfusion. If myocardial ischaemia due to coronary occlusion has been sufficiently prolonged and severe, not only myocyte viability, but also microvascular integrity is lost. Myocardial contrast echocardiography, using intracoronary injection of sonicated contrast medium, gives information about microvascular integrity and the effective presence of intramyocardial reflow. Anatomical integrity of microvasculature does not necessarily imply preserved function, and thus the microvessel vasodilating reserve may also be impaired. Myocardial contrast echocardiography has the potential to assess alterations in microvascular function, showing, in the myocardial area with reduced coronary reserve, a relatively reduced increase in echocontrast signal intensity when an intravenous vasodilator agent is administered.
S Iliceto; V Marangelli; A Marchese; A Amico; L Galiuto; P Rizzon
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European heart journal     Volume:  17     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-09-25     Completed Date:  1996-09-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  344-53     Citation Subset:  IM    
Institute of Cardiology, University of Bari, Italy.
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MeSH Terms
Contrast Media*
Echocardiography / methods*
Myocardial Infarction / pathology,  physiopathology*,  ultrasonography*
Myocardial Reperfusion
Myocardium / pathology
Vascular Patency
Reg. No./Substance:
0/Contrast Media

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