Document Detail

Myocardial contractile state in dogs with chronic mitral regurgitation: echocardiographic approach to the peak systolic pressure/end-systolic area relationship.
MedLine Citation:
PMID:  8322659     Owner:  NLM     Status:  MEDLINE    
Analysis of the pressure-dimension relationship provides a sensitive index of myocardial contractility, but widespread application of this method is limited because it requires invasive measurement techniques. The recent development of two-dimensional echocardiographic automatic boundary detection permits accurate and reproducible on-line measurement of ventricular cavity areas that can be combined with ventricular pressure measurements to derive instantaneous pressure-area relationships. In anesthetized closed-chest dogs with chronic mitral regurgitation, the slope of the ventricular pressure-area relationship was determined by obtaining baseline measurements (at baseline and after infusion of methoxamine or nitroglycerin) and measurements after infusion of a positive inotropic drug (dobutamine) alone and concurrently with methoxamine or nitroglycerin. The slope of the ventricular pressure-area relationship was altered significantly (p = 0.0002) and in the expected direction (steeper slope) from baseline to the enhanced myocardial inotropic state after dobutamine infusion. Thus on-line echocardiographic measurements of ventricular cavity area facilitate the implementation of elastance determinations to serially evaluate the myocardial contractile state under conditions of alterations in preload, afterload, and the inotropic state. This method is promising for the noninvasive evaluation of left ventricular function modified by diverse pathologic conditions.
V G Dávila-Román; L L Creswell; M Rosenbloom; J E Pérez
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American heart journal     Volume:  126     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-08-03     Completed Date:  1993-08-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  155-60     Citation Subset:  AIM; IM    
Cardiovascular Division, Washington University School of Medicine, St. Louis, MO 63110.
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MeSH Terms
Chronic Disease
Dobutamine / pharmacology
Methoxamine / pharmacology
Mitral Valve Insufficiency / physiopathology*,  ultrasonography
Myocardial Contraction / drug effects,  physiology*
Nitroglycerin / pharmacology
Stimulation, Chemical
Stroke Volume* / drug effects
Ventricular Function, Left
Grant Support
Reg. No./Substance:
34368-04-2/Dobutamine; 390-28-3/Methoxamine; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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