Document Detail

Myocardial contractile reserve as prognostic determinant in patients with idiopathic dilated cardiomyopathy without overt heart failure.
MedLine Citation:
PMID:  9041980     Owner:  NLM     Status:  MEDLINE    
To assess the prognostic significance of myocardial contractile reserve in patients with idiopathic dilated cardiomyopathy (DCM) without overt heart failure (New York Heart Association functional class I or II), seventy-one patients underwent exercise radionuclide angiography in addition to clinical, radiographic, hemodynamic, and echocardiographic evaluations. Myocardial contractile reserve was assessed as left ventricular ejection fraction (LVEF) during peak exercise minus LVEF at rest (delta LVEF). During an average of 49 months, 18 patients died of the disease. Cox's proportional-hazards regression analysis showed that the delta LVEF was the most powerful and independent discriminator for survival (p = 0.0002). Ejection time (p = 0.0029) and cardiothoracic ratio (p = 0.017) were the second and third most predictive variables, respectively. Evaluation of the delta LVEF, which reflects residual myocardial contractile reserve, can provide important information about the prognosis of patients with DCM and mild symptoms.
H Nagaoka; N Isobe; S Kubota; T Iizuka; S Imai; T Suzuki; R Nagai
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  111     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-03-21     Completed Date:  1997-03-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  344-50     Citation Subset:  AIM; IM    
Second Department of Internal Medicine, Gumna University School of Medicine, Japan.
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MeSH Terms
Cardiomyopathy, Dilated / mortality,  physiopathology*
Exercise Test
Middle Aged
Myocardial Contraction
Proportional Hazards Models
Radionuclide Angiography
Stroke Volume*
Survival Rate
Ventricular Function, Left*

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