Document Detail


Myocardial cell volume and coronary resistance during diminished coronary perfusion.
MedLine Citation:
PMID:  6433726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was undertaken to determine whether diminished coronary blood flow without abrupt reperfusion results in myocardial cell swelling and, if so, whether the increment in tissue water is related to an increase in coronary vascular resistance. In 19 anesthetized open-chest dogs on right heart bypass with controlled coronary perfusion a decrease in coronary flow resulted in an increase in intracellular water and a progressive increase in coronary resistance. In 15 additional dogs, 180 min of ischemia produced by partially occluding the circumflex coronary artery resulted in significant increases in myocardial water content and progressive decreases in regional myocardial blood flow (microsphere technique). A significant correlation was found between the progressive decreases in myocardial flow and the increases in myocardial water (r = -0.82, P less than 0.001). In five experiments, hypertonic mannitol prevented water accumulation and progressive decreases in blood flow in the ischemic tissue. Thus myocardial ischemia produced by a decrease in antegrade coronary perfusion results in myocardial cell swelling and an associated progressive perfusion deficit.
Authors:
E R Powers; D R DiBona; W J Powell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  247     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-10-24     Completed Date:  1984-10-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H467-77     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Water / metabolism
Cell Count
Coronary Circulation
Coronary Disease / pathology*,  physiopathology
Coronary Vessels / physiopathology*
Dogs
Female
Hemodynamics
Male
Mannitol / pharmacology
Myocardium / metabolism,  pathology*
Osmolar Concentration
Plasma / drug effects
Vascular Resistance*
Grant Support
ID/Acronym/Agency:
1 F32 HL-05886-01/HL/NHLBI NIH HHS; 5P50 HL-17665/HL/NHLBI NIH HHS; HL-07028/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
69-65-8/Mannitol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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