| Myocardial cell injury in septic shock. | |
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MedLine Citation:
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PMID: 10507597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the presence of otherwise undetected myocardial cell injury in patients with septic shock using daily measurements of cardiac troponin I (cTN I). DESIGN: Prospective observational study. SETTING: Intensive care unit of a tertiary institution. PATIENTS: Fifteen consecutive patients with septic shock and six mechanically ventilated patients without septic shock. INTERVENTIONS: Daily collection of blood for the measurement of cTN I serum levels. Regular biochemical and hemodynamic assessment. Illness severity assessment and collection of demographic data. MEASUREMENTS AND MAIN RESULTS: Fifteen patients were studied for a median period of 3 days (range, 1 to 9 days). Serum cTN I concentrations were elevated to values otherwise considered diagnostic of acute myocardial infarction in 12 patients and were significantly higher than in critically ill controls (p = .01). All three patients who died in the intensive care unit and all four patients who did not survive beyond 28 days had elevated levels of cTN I. Survivors tended to lower levels of cTN I while in septic shock than nonsurvivors, and all three patients without increased cTN I survived. There was a significant positive correlation between vasoactive drug requirements and cTN I level (p = .04) and a significant negative correlation between cTN I concentration and left ventricular stroke work index (p = .01). CONCLUSION: Myocardial cell injury appears to be common in patients with septic shock and correlates with cardiac dysfunction. |
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Authors:
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A Turner; M Tsamitros; R Bellomo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Critical care medicine Volume: 27 ISSN: 0090-3493 ISO Abbreviation: Crit. Care Med. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-10-15 Completed Date: 1999-10-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1775-80 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesia and Intensive Care, Austin and Repatriation Medical Center, Heidelberg, Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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APACHE Adult Aged Cardiomyopathies / blood*, drug therapy, etiology*, mortality Case-Control Studies Catecholamines / therapeutic use Creatine Kinase / blood Dose-Response Relationship, Drug Humans Lactic Acid / blood Middle Aged Myocardium / metabolism, pathology* Necrosis Prospective Studies Shock, Septic / complications* Statistics, Nonparametric Survival Analysis Troponin I / blood* Vasoconstrictor Agents / therapeutic use Ventricular Function, Left Victoria / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Troponin I; 0/Vasoconstrictor Agents; 50-21-5/Lactic Acid; EC 2.7.3.2/Creatine Kinase |
| Comments/Corrections | |
Comment In:
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Crit Care Med. 1999 Sep;27(9):2035-6
[PMID:
10507643
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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