| Myocardial catecholamines in hypertrophic and dilated (congestive) cardiomyopathy: a biopsy study. | |
| | |
MedLine Citation:
|
PMID: 6685149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A high performance liquid chromatographic method was used to determine myocardial norepinephrine and epinephrine concentrations in 66 biopsy specimens obtained from the right or left ventricle during routine diagnostic cardiac catheterization of 45 patients with dilated (congestive) or hypertrophic cardiomyopathy, or with heart disease other than cardiomyopathy, such as acute perimyocarditis, postmyocarditis and constrictive pericarditis. The validity of catecholamine determination in a 2 to 6 mg biopsy specimen to assess overall ventricular myocardial catecholamines was demonstrated. Norepinephrine concentrations in the myocardium were inversely correlated with the grade of hypertrophy in patients with congestive cardiomyopathy or heart disease other than cardiomyopathy, but not in patients with hypertrophic cardiomyopathy. The fact that the myocardial norepinephrine concentration was always lower in the left than in the right ventricle of the same patient may be explained by the simple dilution of sympathetic nerve endings in the left ventricle. There were some cases of hypertrophic cardiomyopathy in which the concentration of myocardial norepinephrine was exceptionally high, although its mean value was not significantly higher than that in patients with other types of heart disease who served as a control group without cardiomyopathy. Some patients with dilated cardiomyopathy had lower levels of myocardial norepinephrine than would be expected for the degree of interstitial fibrosis and the severity of heart failure. The mean plasma norepinephrine and epinephrine levels were significantly elevated in patients with dilated cardiomyopathy. |
| | |
Authors:
|
C Kawai; Y Yui; T Hoshino; S Sasayama; A Matsumori |
Related Documents
:
|
12808279 - Sudden death of a case of hypertrophic obstructive cardiomyopathy 19 months after succe... 3745719 - Reversal of left ventricular intracavitary gradient with intracavitary diastolic regurg... 12517069 - Arrhythmogenic right ventricular cardiomyopathy: three cases. 16315829 - The usual causes of left ventricular outflow tract obstruction below the aortic valve i... 17213299 - Comprehensive multidetector ct assessment of apical hypertrophic cardiomyopathy. 8798109 - Determinants of prognosis in nonischemic dilated cardiomyopathy. 21701699 - Gene therapy for myocardial infarction-associated congestive heart failure: how far hav... 20606789 - Concept of the five 'a's for treating emergency arrhythmias. 1579529 - Cor pulmonale. treatment implications of right versus left ventricular impairment. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of the American College of Cardiology Volume: 2 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 1983 Nov |
Date Detail:
|
Created Date: 1983-12-17 Completed Date: 1983-12-17 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 834-40 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Biopsy Cardiomyopathy, Dilated / etiology, metabolism*, pathology Cardiomyopathy, Hypertrophic / etiology, metabolism*, pathology Catecholamines / analysis, metabolism* Chromatography, High Pressure Liquid Female Heart Catheterization Heart Failure / metabolism* Histocytochemistry Humans Male Middle Aged Myocardium / analysis, metabolism*, pathology |
| Chemical | |
Reg. No./Substance:
|
0/Catecholamines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Continuous elevation of blood growth hormone concentrations by beeswax implant.
Next Document: Comparison of the effects of nitroprusside and nifedipine on diastolic properties in patients with h...