Document Detail


Myocardial catecholamines following cold cardioplegic arrest during open-heart surgery.
MedLine Citation:
PMID:  6528267     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preservation of both right and left ventricular subendocardial and subepicardial muscle was assessed using quantitative polarization microscopy (birefringence measurements) with preservation of myocardial catecholamines measured by fluorescence microscopy in biopsies from 20 consecutive patients who underwent open heart surgery with cold cardioplegic arrest (St. Thomas' Solution). Six of the 7 patients with clinical complications were predicted from the birefringence results. One developed left ventricular deterioration during bypass, two patients right ventricular deterioration, one patient both left and right ventricular deterioration and two patients had poor left ventricular function before bypass. Birefringence measurements were thus reliable in predicting post-operative cardiac outcome. There were no significant changes during the bypass period in the catecholamine scores, even in those patients who had clinical complications. Fluorescence microscopy showed that the "free" myocardial nerve net and the pericoronary nerve plexuses retained their catecholamine stores equally well. This indicated that St. Thomas' cardioplegia preserves myocardial catecholamine stores, depletion of which would remove a potentially important compensatory mechanism in cardiac pump failure. There may however be a temporary blockade in the release of endogenous cardiac catecholamine (noradrenaline) stores from the adrenergic nerve terminals following cold cardioplegic arrest despite myocardial pump failure.
Authors:
K T Kyösola; M V Braimbridge; S Darracott-Canković; D J Chambers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of thoracic and cardiovascular surgery     Volume:  18     ISSN:  0036-5580     ISO Abbreviation:  Scand J Thorac Cardiovasc Surg     Publication Date:  1984  
Date Detail:
Created Date:  1985-04-12     Completed Date:  1985-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0121343     Medline TA:  Scand J Thorac Cardiovasc Surg     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  209-15     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biopsy
Birefringence
Cardiac Surgical Procedures*
Coronary Vasospasm / chemically induced
Heart / physiopathology
Heart Arrest, Induced*
Humans
Microscopy, Fluorescence
Middle Aged
Myocardium / metabolism*,  pathology
Norepinephrine / metabolism*
Postoperative Complications / prevention & control
Chemical
Reg. No./Substance:
51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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