| Myocardial catecholamine metabolism in patients with chronic aortic regurgitation. | |
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MedLine Citation:
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PMID: 7083533 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 17 patients suffering from severe chronic aortic regurgitation (AR) (New York Heart Association functional class III), right atrial biopsies were taken during aortic valve replacement. In these samples, we determined the myocardial content of norepinephrine (NE), normetanephrine (NM), epinephrine (E) and dopamine (DA). Two to 4 days before valve replacement, plasma catecholamines were measured at rest and during isometric exercise. Fifteen patients with secundum atrial septal defect (ASD) served as controls. In patients with chronic AR who had no clinical signs of cardiac failure, the myocardial content of NE (p less than 0.025), NM (p less than 0.05) and E (p less than 0.05) was significantly reduced compared with that in patients with ASD. The right atrial content of DA was not different in the two groups. All patients had normal levels of plasma catecholamines at rest. During isometric exercise, however, the increase in plasma NE was significantly higher in patients with AR than in the control group (p less than 0.005). We conclude that patients with chronic AR who have an exaggerated increase in sympathetic activity during isometric exercise probably have a decrease in myocardial NE tissue content as well. Therefore, clinical demonstration of a hyperadrenergic response during isometric exercise indicates alteration in myocardial metabolism in patients with severe chronic AR. |
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Authors:
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W Mäurer; A Ablasser; R Tschada; M Hausen; W Saggau; W Kübler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Circulation Volume: 66 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1982 Aug |
Date Detail:
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Created Date: 1982-08-26 Completed Date: 1982-08-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: I139-42 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aortic Valve / surgery Aortic Valve Insufficiency / metabolism*, surgery Catecholamines / metabolism* Chronic Disease Female Heart Septal Defects, Atrial / complications Heart Valve Prosthesis Humans Isometric Contraction Male Middle Aged Myocardium / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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