Document Detail

Myocardial catecholamine balance during angina: effects of calcium entry blockers, verapamil and nifedipine.
MedLine Citation:
PMID:  3966338     Owner:  NLM     Status:  MEDLINE    
To evaluate the effects of calcium entry blocking agents on cardiac sympathetic tone during angina pectoris, arterial and coronary sinus (CS) norepinephrine (NE) and epinephrine (E) concentrations and CS blood flow were determined at rest and during pacing-induced angina, both before and after verapamil in nine patients and after nifedipine in nine patients, all of whom had fixed obstructive coronary artery disease. Resting arterial NE and E concentrations and myocardial NE release and E uptake remained unchanged during angina before verapamil and nifedipine, suggesting unaltered systemic and cardiac sympathetic tone and myocardial E handling. Following verapamil and nifedipine, arterial NE and E concentrations remained unchanged. After verapamil, net myocardial NE release increased from 16,072 +/- 18,881 to 35,520 +/- 30,595 at preverapamil angina rate (p less than 0.01) and to 39,643 +/- 29,728 pg/min at postverapamil angina rate (p less than 0.01). NE release after nifedipine increased from -4207 +/- 8898 to 10,988 +/- 30,711 (p less than 0.05) at prenifedipine angina rate and to 19,942 +/- 26,644 pg/min (p less than 0.05) at postnifedipine angina rate. NE release was independent of changes in CS flow after verapamil or nifedipine. E uptake after verapamil and nifedipine remained unchanged. Although the precise mechanism is not known, myocardial alpha-adrenergic receptor blockage with verapamil and nifedipine remains a possible explanation for increased myocardial NE release.
J L Rouleau; K Chatterjee; W W Parmley; P Kramer; K Swedberg; D Curran; M Namekawa
Related Documents :
731298 - An investigation with serial angiography into the evolution of cerebral arterial spasm ...
11265718 - Thoracic location of the lead with maximal st-segment deviation during posterior and ri...
21830458 - Moyamoya disease in a patient with brain tumor: case report.
6770668 - Relation of coronary arterial spasm to sites of organic stenosis.
666428 - Sinus venosus atrial septal defect associated with partial anomalous pulmonary venous d...
7350338 - Successful use of a paracorporeal left ventricular assist device in man.
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  109     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-02-21     Completed Date:  1985-02-21     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  201-9     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Angina Pectoris / drug therapy*,  metabolism
Catecholamines / metabolism*
Epinephrine / metabolism
Heart / drug effects*,  innervation
Middle Aged
Myocardium / metabolism*
Nifedipine / pharmacology*
Norepinephrine / metabolism
Sympathetic Nervous System / drug effects*
Verapamil / pharmacology*
Reg. No./Substance:
0/Catecholamines; 21829-25-4/Nifedipine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 52-53-9/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Value of two-dimensional echocardiographic detection of incomplete mitral leaflet closure.
Next Document:  The effect of dextro-, levo-, and racemic verapamil on atrioventricular conduction in humans.