Document Detail


Myocardial catecholamine balance during angina: effects of calcium entry blockers, verapamil and nifedipine.
MedLine Citation:
PMID:  3966338     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the effects of calcium entry blocking agents on cardiac sympathetic tone during angina pectoris, arterial and coronary sinus (CS) norepinephrine (NE) and epinephrine (E) concentrations and CS blood flow were determined at rest and during pacing-induced angina, both before and after verapamil in nine patients and after nifedipine in nine patients, all of whom had fixed obstructive coronary artery disease. Resting arterial NE and E concentrations and myocardial NE release and E uptake remained unchanged during angina before verapamil and nifedipine, suggesting unaltered systemic and cardiac sympathetic tone and myocardial E handling. Following verapamil and nifedipine, arterial NE and E concentrations remained unchanged. After verapamil, net myocardial NE release increased from 16,072 +/- 18,881 to 35,520 +/- 30,595 at preverapamil angina rate (p less than 0.01) and to 39,643 +/- 29,728 pg/min at postverapamil angina rate (p less than 0.01). NE release after nifedipine increased from -4207 +/- 8898 to 10,988 +/- 30,711 (p less than 0.05) at prenifedipine angina rate and to 19,942 +/- 26,644 pg/min (p less than 0.05) at postnifedipine angina rate. NE release was independent of changes in CS flow after verapamil or nifedipine. E uptake after verapamil and nifedipine remained unchanged. Although the precise mechanism is not known, myocardial alpha-adrenergic receptor blockage with verapamil and nifedipine remains a possible explanation for increased myocardial NE release.
Authors:
J L Rouleau; K Chatterjee; W W Parmley; P Kramer; K Swedberg; D Curran; M Namekawa
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  109     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-02-21     Completed Date:  1985-02-21     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  201-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Angina Pectoris / drug therapy*,  metabolism
Catecholamines / metabolism*
Epinephrine / metabolism
Heart / drug effects*,  innervation
Humans
Middle Aged
Myocardium / metabolism*
Nifedipine / pharmacology*
Norepinephrine / metabolism
Sympathetic Nervous System / drug effects*
Verapamil / pharmacology*
Chemical
Reg. No./Substance:
0/Catecholamines; 21829-25-4/Nifedipine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 52-53-9/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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