| Myocardial bridging, a frequent component of the hypertrophic cardiomyopathy phenotype, lacks systematic association with sudden cardiac death. | |
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MedLine Citation:
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PMID: 19406869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The clinical significance attributable to myocardial bridging of left anterior descending coronary artery in hypertrophic cardiomyopathy (HCM) remains controversial. METHODS AND RESULTS: Prevalence and depth of coronary artery bridges (CBs) were assessed in 255 hearts, including 115 with HCM (median age 29, range 5-90; 75% male), and 140 controls. Coronary artery bridges were more common in HCM (47/115; 41%) than in patients who died of a variety of non-HCM-related causes (21/100; 21%; P = 0.002), or in patients with congenital aortic stenosis and left ventricular (LV) hypertrophy (5/40; 12%; P = 0.001). Among the HCM hearts, CBs were present in 33 of 77 patients (43%) with sudden death, in 10 of 27 (37%) with heart failure death (or heart transplantation), and in 4 of 11 (36%) with other modes of death (P = 0.826). Deeply embedded CBs (> or =2 mm) occurred with similar frequency in HCM patients with sudden (21 of 77; 27%) or heart failure death (5 of 27; 13%; P = 0.191). In sudden death patients, the presence of CB was unrelated to gender (33% in women and 45% in men, P = 0.406) and age (41% <18 years vs. 44% > or =18 years; P = 0.827). CONCLUSION: In this morphological analysis of more than 250 hearts, CBs are a frequent component of phenotypically expressed HCM, and more common than in other disorders with or without LV hypertrophy. Although no systematic association with HCM-related sudden death is evident, our findings do not exclude the possibility that CB could contribute to increased risk in some individual patients, potentially impacting management decision-making on a case-by-case basis. |
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Authors:
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Cristina Basso; Gaetano Thiene; Shannon Mackey-Bojack; Anna Chiara Frigo; Domenico Corrado; Barry J Maron |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-30 |
Journal Detail:
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Title: European heart journal Volume: 30 ISSN: 1522-9645 ISO Abbreviation: Eur. Heart J. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-02 Completed Date: 2009-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 1627-34 Citation Subset: IM |
Affiliation:
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Department of Medico-Diagnostic Sciences, Pathological Anatomy, University of Padua Medical School, Padova, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aged Aged, 80 and over Cardiomyopathy, Hypertrophic / complications*, pathology Child Child, Preschool Cicatrix / complications Coronary Disease / complications Death, Sudden, Cardiac / etiology*, pathology Female Heart Ventricles / pathology Humans Male Middle Aged Myocardial Bridging / complications*, pathology Retrospective Studies Sex Factors Young Adult |
| Comments/Corrections | |
Comment In:
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Eur Heart J. 2009 Jul;30(13):1549-50
[PMID:
19491131
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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