| Myocardial blood flow regulation relative to left ventricle pressure and volume in anesthetized dogs. | |
| | |
MedLine Citation:
|
PMID: 10593664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The influence of left ventricle pressure and volume changes on coronary blood flow was investigated in eight anesthetized dogs. Coronary artery pressure-flow relationships were determined at two levels of left ventricular pressure and volume. The distribution of blood flow within the myocardium was also determined when these relationships varied. Reducing left ventricle pressures and volumes increased heart rate. Rate-pressure product, diastolic coronary pressure, myocardial O2 consumption, total, subendocardial and subepicardial flow decreased. Hematocrit and blood gas data were unchanged. The pressure-flow relationships were shifted leftward (p = 0.001) but the range of autoregulation was not altered. At low left ventricle pressures and volumes, the lower coronary artery pressure limit was shifted leftward (from 75 to 45 mm Hg (1 mm Hg = 133.3 Pa)), while total, subendocardial, and subepicardial blood flow did not change compared with the control. Below the lower coronary artery pressure limit, subendocardial but not subepicardial flow decreased, resulting in maldistribution of flow across the left ventricular wall. When coronary pressure was reset between control and the lower coronary artery pressure limit, subendocardial flow was restored. These results show that the lower coronary artery pressure limit can be shifted leftward while the distribution of blood flow across the left ventricular wall is preserved. |
| | |
Authors:
|
J R Rouleau; D Simard; J G Kingma |
Related Documents
:
|
9577944 - Effects of cardiac versus circulatory angiotensin-converting enzyme inhibition on left ... 8348574 - Arteriovenous-shunt-mediated increase in venous return causes apparent right coronary a... 2425164 - Effects of felodipine on pacing-induced angina pectoris. 1647274 - Impaired diastolic function and coronary reserve in genetic hypertension. role of inter... 17951744 - Fluorescence microscopy to study pressure between lipids in giant unilamellar vesicles. 6811524 - Brain extracellular fluid ph and blood flow during isocapnic and hypocapnic hypoxia. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Canadian journal of physiology and pharmacology Volume: 77 ISSN: 0008-4212 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 1999 Nov |
Date Detail:
|
Created Date: 1999-12-30 Completed Date: 1999-12-30 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: CANADA |
Other Details:
|
Languages: eng Pagination: 902-8 Citation Subset: IM |
Affiliation:
|
Université Laval and Quebec Heart Institute, Department of Cardiology, Laval Hospital, Ste-Foy, Canada. jacques-r.rouleau@med.ulaval.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anesthesia Animals Blood Gas Analysis Cardiac Volume / physiology* Coronary Circulation / physiology* Dogs Hematocrit Hemodynamics / physiology Homeostasis / physiology* Male Myocardium / metabolism Oxygen Consumption Respiration, Artificial Ventricular Function, Left / physiology* Ventricular Pressure / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cytosolic fatty acid binding protein enhances rat hepatocyte [3H]palmitate uptake.
Next Document: Effects of pregnancy and chronic exercise on maternal cardiac structure and function.