Document Detail

Myocardial blood flow measurements in rats with simple pulsing contrast echocardiography.
MedLine Citation:
PMID:  12049959     Owner:  NLM     Status:  MEDLINE    
Relationship between contrast intensity and ultrasound (US) pulsing interval has been utilized to quantify myocardial blood flow (MBF) during myocardial contrast echocardiography (MCE). We tested if an MCE method employing a simple pulsing sequence during intravenous contrast infusion has the ability to quantify MBF in rats. We performed MCE in 17 rats using a 5- to 12-MHz broadband transducer during microbubble infusion via the femoral vein. Acoustic density (AD) from the anterior wall of the left ventricle imaged in the short axis plane was plotted against the frame number after shortening the pulsing interval (PI) from 1:20 to 1:1 end-systolic ECG gating. The relation between AD and frame number was fitted to a decay function. The rate of the AD decay was decreased during dipyridamole infusion, but was increased by causing coronary stenosis. The AD during long PI imaging remained unchanged during the interventions. Estimated MBF by MCE after correction by heart rate exhibited a close correlation (r = 0.83) with the present "gold standard" of colored microsphere-derived MBF. Thus, the decay rate of the contrast intensity obtained with the high-frequency transducer after abrupt shortening of PI during intravenous microbubble infusion may provide for noninvasive measurement of MBF in rats.
Akira Oshita; Koji Ohmori; Yang Yu; Isao Kondo; Hiroto Takeuchi; Yuichiro Takagi; Yoshihiro Wada; Kazushi Yukiiri; Katsufumi Mizushige; Masakazu Kohno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  28     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-06-06     Completed Date:  2002-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  459-66     Citation Subset:  IM    
Kagawa Medical University School of Medicine, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, Japan.
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MeSH Terms
Blood Flow Velocity
Contrast Media
Coronary Circulation / physiology*
Echocardiography / methods*
Models, Animal
Myocardial Ischemia / physiopathology,  ultrasonography
Pulsatile Flow
Rats, Sprague-Dawley
Reg. No./Substance:
0/Contrast Media

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