| Myocardial blood flow during exercise after gradual coronary occlusion in the dog. | |
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MedLine Citation:
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PMID: 6869554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myocardial blood flow was studied with radioactive microspheres in 14 dogs 1 mo after placement of an Ameroid constrictor on either the left circumflex or the left anterior descending coronary artery to result in total coronary occlusion without myocardial infarction, as well as in 7 normal control dogs. Measurements were performed during quiet resting conditions and during two levels of treadmill exercise to achieve heart rates of approximately 180 (light exercise) and 230 beats/min (heavy exercise). During resting conditions myocardial blood flow in the collateral-dependent area was normal in all dogs. Three different patterns of response occurred during treadmill exercise in the animals with coronary occlusion. In five dogs, both the volume and transmural distribution of myocardial blood flow behaved similarly to the normal dogs at both exercise levels. In five dogs, blood flow behaved normally during light exercise, but during heavy exercise a transmural redistribution of perfusion occurred in the collateralized area to result in subendocardial underperfusion. Finally, in four dogs even light exercise resulted in subendocardial underperfusion in the collateral-dependent area, whereas further increasing the exercise load resulted in an actual decrease of subendocardial blood flow below the resting level. These data demonstrated that although resting myocardial blood flow was normal in the collateral-dependent area 1 mo after Ameroid implantation, a markedly heterogeneous response occurred during exercise, ranging from a completely normal response to a severe degree of exercise-induced subendocardial underperfusion. |
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Authors:
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R J Bache; J S Schwartz |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 245 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1983 Jul |
Date Detail:
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Created Date: 1983-08-11 Completed Date: 1983-08-11 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H131-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Coronary Circulation* Dogs Endocardium / physiology Heart Rate Microspheres Physical Exertion* Radioisotopes / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
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HL-20598/HL/NHLBI NIH HHS; HL-21872/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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