Document Detail


Myocardial blood flow during acute isovolumic anemia and treadmill exercise in dogs.
MedLine Citation:
PMID:  6181044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined whether submaximal treadmill exercise during acute isovolumic anemia altered the distribution of myocardial blood flow and thus caused subendocardial ischemia in unsedated dogs. Myocardial blood flow (determined by the microsphere method) and left ventricular function (indicated by pressures, volumes, and contractile indices) were measured in five dogs at rest and during exercise before and after equal volume exchange of blood and 6% dextran 70, which lowered hematocrit from 36 +/- 4 to 18 +/- 2% (SD). Total myocardial blood flow increased from 175 +/- 65 to 296 +/- 151 ml . min-1 . 100 g-1 (69%) during exercise before anemia and from 329 +/- 61 to 599 +/- 126 (82%) during exercise after anemia. The distribution of blood flow to the left and right ventricles and interventricular septum as well as the subendothelial-to-subepicardial blood flow ratio in these areas did not change during exercise either before or after anemia. Left ventricular function was not impaired during exercise after anemia. We conclude that subendocardial ischemia does not occur when dogs exercise during acute isovolumic anemia.
Authors:
D R Abendschein; J E Fewell; C J Carlson; E Rapaport
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  53     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  203-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Anemia / etiology,  physiopathology*
Animals
Blood Pressure
Cardiac Output
Coronary Circulation*
Dextrans / administration & dosage
Dogs
Endocardium / physiology
Erythrocyte Volume
Pericardium / physiology
Physical Exertion*
Stroke Volume
Grant Support
ID/Acronym/Agency:
HL-07159/HL/NHLBI NIH HHS; HL-07192/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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