Document Detail


Myocardial blood flow and adenosine A2A receptor density in endurance athletes and untrained men.
MedLine Citation:
PMID:  18772204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous human studies have shown divergent results concerning the effects of exercise training on myocardial blood flow (MBF) at rest or during adenosine-induced hyperaemia in humans. We studied whether these responses are related to alterations in adenosine A2A receptor (A2AR) density in the left-ventricular (LV) myocardium, size and work output of the athlete's heart, or to fitness level. MBF at baseline and during intravenous adenosine infusion, and A2AR density at baseline were measured using positron emission tomography, and by a novel A(2A)R tracer in 10 healthy male endurance athletes (ET) and 10 healthy untrained (UT) men. Structural LV parameters were measured with echocardiography. LV mass index was 71% higher in ET than UT (193 +/- 18 g m(-2) versus 114 +/- 13 g m(-2), respectively). MBF per gram of tissue was significantly lower in the ET than UT at baseline, but this was only partly explained by reduced LV work load since MBF corrected for LV work was higher in ET than UT, as well as total MBF. The MBF during adenosine-induced hyperaemia was reduced in ET compared to UT, and the fitter the athlete was, the lower was adenosine-induced MBF. A2AR density was not different between the groups and was not coupled to resting or adenosine-mediated MBF. The novel findings of the present study show that the adaptations in the heart of highly trained endurance athletes lead to relative myocardial 'overperfusion' at rest. On the other hand hyperaemic perfusion is reduced, but is not explained by A2AR density.
Authors:
Ilkka Heinonen; Sergey V Nesterov; Kaisa Liukko; Jukka Kemppainen; Kjell Någren; Matti Luotolahti; Pauliina Virsu; Vesa Oikonen; Pirjo Nuutila; Urho M Kujala; Heikki Kainulainen; Robert Boushel; Juhani Knuuti; Kari K Kalliokoski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-04
Journal Detail:
Title:  The Journal of physiology     Volume:  586     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-03     Completed Date:  2009-03-16     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  5193-202     Citation Subset:  IM    
Affiliation:
Turku PET Centre, Departments of Clinical Physiology and Nuclear Medicine, University of Turku, Turku, Finland. ilkka.heinonen@tyks.fi
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Flow Velocity / physiology
Coronary Circulation / physiology*
Exercise / physiology
Heart / physiology*
Humans
Male
Physical Endurance / physiology*
Receptor, Adenosine A2A / metabolism*
Chemical
Reg. No./Substance:
0/Receptor, Adenosine A2A
Comments/Corrections
Comment In:
J Physiol. 2008 Nov 1;586(Pt 21):5043   [PMID:  18978161 ]

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