| Myocardial beta-adrenoceptor density one month after acute myocardial infarction predicts left ventricular volumes at six months. | |
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MedLine Citation:
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PMID: 12383568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate whether myocardial beta-adrenoceptor (beta-AR) downregulation precedes and predicts left ventricular (LV) dilation after acute myocardial infarction (AMI), we measured beta-AR density within four weeks of AMI and correlated it with serial measurements of LV volumes. BACKGROUND: Patients who develop heart failure following AMI have an increased sympathetic drive to the heart within the first four weeks after infarction. METHODS: We prospectively studied 61 patients in whom AMI was the first presentation of coronary artery disease (CAD) and with no signs of heart failure. The LV volumes were measured one, three, and six months after AMI by echocardiography. Beta-AR density was measured using positron emission tomography with S-[(11)C]CGP 12177. Seventeen matched healthy volunteers served as controls. RESULTS: Whole heart beta-AR density was lower in patients than in controls (6.25 +/- 0.98 pmol/g vs. 8.32 +/- 2.14 pmol/g, p < 0.0001). In patients, beta-AR density was inversely correlated with end-systolic and end-diastolic volumes six months after AMI. Patients whose LV was dilated at six months had a lower beta-AR density in noninfarcted myocardium than patients without dilation (6.15 pmol/g vs. 6.98 pmol/g, p = 0.008). In addition, beta-AR density in noninfarcted myocardium was higher when the infarct-related artery was patent (6.87 +/- 1.14 pmol/g vs. 5.76 +/- 0.86 pmol/g occluded, p < 0.01). CONCLUSIONS: Myocardial beta-AR density is reduced after AMI in the absence of heart failure, and the reduction predicts later LV dilation. These data are suggestive of an enhanced sympathetic drive to the heart, having an important etiologic role in LV remodeling after AMI. |
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Authors:
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Nicos Spyrou; Stuart D Rosen; Farzin Fath-Ordoubadi; Rohan Jagathesan; Rodney Foale; Jaspal S Kooner; Paolo G Camici |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 40 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-10-17 Completed Date: 2002-11-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1216-24 Citation Subset: AIM; IM |
Affiliation:
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Medical Research Council Clinical Sciences Centre and National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, United Kingdom. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Case-Control Studies Catecholamines / blood Disease Progression Down-Regulation* Echocardiography Female Heart Failure / etiology Humans Hypertrophy, Left Ventricular / etiology*, physiopathology Male Middle Aged Myocardial Infarction / blood, complications*, pathology*, therapy Predictive Value of Tests Prospective Studies Receptors, Adrenergic, beta / analysis*, genetics Severity of Illness Index Stroke Volume Time Factors Tomography, Emission-Computed Treatment Outcome Ventricular Function, Left Ventricular Remodeling* |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Receptors, Adrenergic, beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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