Document Detail

Myocardial adaptation to exercise training: a view through positron emission tomography.
MedLine Citation:
PMID:  9800884     Owner:  NLM     Status:  MEDLINE    
Myocardial adaptation to exercise training includes changes in morphology, energy metabolism and autonomic control. Positron emission tomography (PET) provides a tool for investigating tissue perfusion, metabolism and neurotransmission in vivo. Combined with echocardiography, magnetic resonance imaging and assessment of cardiovascular autonomic nervous function, this technology allows us to study the effects of exercise training on cardiac physiology in a noninvasive way. For example, exercise-induced increases in coronary blood flow have been quantified in myocardial segments supplied by angiographically normal as well as diseased vessels. Recent studies have shown that adaptive changes of energy substrate utilization occur in the athlete's heart. Simulation of physical exercise by dobutamine infusion has been used to study demand-induced changes in cardiac energetics and efficiency. Studies on the dysfunctionally hibernating myocardium have outlined the consequences of exercise-induced ischaemia, whereas in heart failure exercise training may normalize myocardial hypoperfusion and sympathetic denervation. In conclusion, PET has matured to a very informative clinical research tool which, particularly in combination with other imaging modalities, has brought into attention previously unaccessible features of cardiovascular physiology.
L M Voipio-Pulkki
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of medicine     Volume:  30 Suppl 1     ISSN:  0785-3890     ISO Abbreviation:  Ann. Med.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1999-01-19     Completed Date:  1999-01-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8906388     Medline TA:  Ann Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  54-60     Citation Subset:  IM    
Department of Medicine, University of Turku, Turku University Central Hospital, Finland.
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MeSH Terms
Adaptation, Physiological
Coronary Circulation / physiology*
Exercise / physiology*
Myocardial Ischemia / physiopathology*,  radionuclide imaging*
Physical Education and Training
Sensitivity and Specificity
Tomography, Emission-Computed

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