| Myocardial T2* measurements in iron-overloaded thalassemia: An in vivo study to investigate optimal methods of quantification. | |
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MedLine Citation:
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PMID: 18956471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reproducible and accurate myocardial T2* measurements are required for the quantification of iron in heart tissue in transfused thalassemia. The aim of this study was to determine the best method to measure the myocardial T2* from multi-gradient-echo data acquired both with and without black-blood preparation. Sixteen thalassemia patients from six centers were scanned twice locally, within 1 week, using an optimized bright-blood T2* sequence and then subsequently scanned at the standardization center in London within 4 weeks, using a T2* sequence both with and without black-blood preparation. Different curve-fitting models (monoexponential, truncation, and offset) were applied to the data and the results were compared by means of reproducibility. T2* measurements obtained using the bright- and black-blood techniques. The black-blood data were well fitted by the monoexponential model, which suggests that a more accurate measure of T2* can be obtained by removing the main source of errors in the bright-blood data. For bright-blood data, the offset model appeared to underestimate T2* values substantially and was less reproducible. The truncation model gave rise to more reproducible T2* measurements, which were also closer to the values obtained from the black-blood data. |
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Authors:
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Taigang He; Peter D Gatehouse; Gillian C Smith; Raad H Mohiaddin; Dudley J Pennell; David N Firmin |
Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 60 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-03 Completed Date: 2009-02-12 Revised Date: 2010-09-21 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 1082-9 Citation Subset: IM |
Affiliation:
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National Heart and Lung Institute, Imperial College London, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Algorithms Female Great Britain Humans Image Enhancement / methods Image Interpretation, Computer-Assisted / methods* Iron / analysis* Iron Overload / diagnosis*, metabolism* Magnetic Resonance Imaging / methods* Male Myocardium / metabolism* Reproducibility of Results Sensitivity and Specificity Thalassemia / diagnosis*, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK066084-04/DK/NIDDK NIH HHS; R01 DK66084-01/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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7439-89-6/Iron |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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