Document Detail

Myocardial T1: Quantification by Using an ECG-triggered Radial Single-Shot Inversion-Recovery MR Imaging Sequence.
MedLine Citation:
PMID:  25393945     Owner:  NLM     Status:  Publisher    
Purpose To develop and validate a fast cardiac magnetic resonance imaging T1 mapping technique with high spatial resolution based on a radial inversion-recovery ( IR inversion recovery ) spoiled gradient-echo acquisition. Materials and Methods Approval for the study was granted by the local institutional review board, and all subjects gave written informed consent. An electrocardiographically triggered radial single-shot IR inversion recovery ( TRASSI ECG-triggered radial single-shot IR ) sequence was developed in conjunction with a custom-written fitting algorithm. The proposed imaging technique was validated in phantom measurements and then used for cardiac T1 mapping in 62 subjects with or without cardiac disease. The study population included 51 healthy subjects, three patients with arrhythmia, and eight patients with myocardial infarction. The potential heart rate dependency of the TRASSI ECG-triggered radial single-shot IR method was tested by using linear regression analysis. Statistically significant differences between the sexes and various section orientations were analyzed with a Student t test for independent groups and a repeated-measures analysis of variance for dependent groups. Results High-spatial-resolution T1 maps (1.17 × 1.17 mm) without motion artifacts and without heart rate dependency (slope = -0.0303, R(2) = 0.0000887, P = .899) were acquired with an acquisition time of less than 6 seconds in all subjects. The mean T1 of healthy left ventricular myocardium across all examined subjects was 1031 msec ± 33 (standard deviation). Testing for reproducibility in three individuals with 34 repetitive measurements revealed a mean standard deviation of 4.1 msec (0.412%). Subacute and chronic myocardial infarction could be detected in all eight patients. T1 disturbances due to arrhythmia proved to be minimal in three patients (standard deviation, <1.2%). Conclusion Fast and accurate cardiac T1 mapping is feasible within a single-shot IR inversion recovery experiment. © RSNA, 2014 Online supplemental material is available for this article.
Daniel Gensler; Philipp Mörchel; Florian Fidler; Oliver Ritter; Harald H Quick; Mark E Ladd; Wolfgang R Bauer; Georg Ertl; Peter M Jakob; Peter Nordbeck
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-13
Journal Detail:
Title:  Radiology     Volume:  -     ISSN:  1527-1315     ISO Abbreviation:  Radiology     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-13     Completed Date:  -     Revised Date:  2014-11-14    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  131295     Citation Subset:  -    
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