Document Detail

Myocardial SPECT perfusion defect size compared to infarct size by delayed gadolinium-enhanced magnetic resonance imaging in patients with acute or chronic infarction.
MedLine Citation:
PMID:  15522048     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Single photon emission computed tomography (SPECT) perfusion imaging has been considered a reference method for non-invasive estimation of infarct size in man. Recently, delayed gadolinium-enhanced magnetic resonance imaging (DE-MRI) has evolved as an accurate tool to quantify infarct size. Therefore, the present study was designed to compare perfusion defect size by SPECT to hyperenhanced volume by DE-MRI. METHODS: DE-MRI was performed in 30 patients. Fourteen were patients with revascularized first-time acute infarctions, eight revascularized chronic infarctions, and eight clinically referred non-revascularized patients. SPECT was performed in the same patients and analysed by a commercial package. RESULTS: The hypoperfused volume by SPECT was larger than the hyperenhanced volume by DE-MRI by 8 +/- 8 ml (6% +/- 5 percentage points), 10 +/- 18 ml (6% +/- 11 percentage points), and 26 +/- 30 ml (12% +/- 10 percentage points) in the acute, chronic and clinical populations, respectively. Left ventricle wall volume was smaller by SPECT in all settings. CONCLUSION: The SPECT perfusion defect size was comparable with but generally slightly larger than the hyperenhanced volume by DE-MRI in both absolute and relative terms in patients with acute and chronic infarction. The results may be related to systematic differences between modalities but could also be influenced by biological phenomena such as wall thinning or hypoperfused but viable myocardium.
Erik Hedström; John Palmer; Martin Ugander; Håkan Arheden
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  24     ISSN:  1475-0961     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-03     Completed Date:  2005-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  380-6     Citation Subset:  IM    
Department of Clinical Physiology, Lund University Hospital, SE-221 85 Lund, Sweden.
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MeSH Terms
Acute Disease
Chronic Disease
Contrast Media
Heterocyclic Compounds / diagnostic use*
Magnetic Resonance Imaging / methods*
Middle Aged
Myocardial Infarction / classification*,  complications,  diagnosis*,  radionuclide imaging
Organometallic Compounds / diagnostic use*
Reproducibility of Results
Sensitivity and Specificity
Severity of Illness Index
Tomography, Emission-Computed, Single-Photon / methods*
Ventricular Dysfunction, Left / classification*,  complications,  diagnosis*,  radionuclide imaging
Reg. No./Substance:
0/Contrast Media; 0/Heterocyclic Compounds; 0/Organometallic Compounds; 92923-44-9/gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate

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