Document Detail

Myocardial Protection in Donor Heart Preservation: A Comparison Between Bretschneider's Histidine-Tryptophan-Ketoglutarate Solution and Cold Blood Cardioplegia.
MedLine Citation:
PMID:  24815133     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Optimal myocardial protection for donated hearts is crucial to improve outcomes of heart transplantation and reduce morbidity and mortality. This study aimed to compare the efficacy of myocardial protection using single dose of Bretschneider's histidine-tryptophan-ketoglutarate (HTK) solution and repeated doses of cold blood cardioplegia (CBC) in donor heart preservation.
METHODS: Sixty-seven patients undergoing heart transplantation in Tri-Service General Hospital, Taipei, Taiwan between 2002 and 2012 were enrolled in this study. Patients were divided into an HTK group and a CBC group based on the preservation solution used to protect the donated hearts. The perioperative variables and postoperative outcomes were retrospectively reviewed.
RESULTS: There were no statistic differences about demographic data in donors and recipients between the 2 groups. There were no significant differences in postoperative cardiac enzymes, hemodynamic data, length of stay in intensive care, or 30-day mortality between the groups. The HTK group showed a trend of shorter pumping time (P = .091). Multivariate analyses reveal that the HTK group had higher postoperative inotropic score (P < .001) and shorter pumping time (P = .02).
CONCLUSIONS: Single dose of Bretschneider's HTK solution could effectively reduce pumping time and afford similar myocardial protection compared with repeated doses of CBC in the preservation of donated hearts.
S-Y Sung; C-Y Lin; J-Y Song; Y-T Tsai; C-H Kao; C-Y Lee; Y-C Lin; P-S Hsu; C-S Tsai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  46     ISSN:  1873-2623     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-05-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1077-81     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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