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Myocardial Perfusion Reserve Assessed by T2-Prepared Steady-State Free-Precession Blood Oxygen Level-Dependent (BOLD) Magnetic Resonance Imaging in Comparison to Fractional Flow Reserve.
MedLine Citation:
PMID:  22855554     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: -BOLD CMR has been shown to be able to detect myocardial perfusion differences. However, validation of BOLD CMR against FFR is lacking. Aim of our study was to analyze the potential diagnostic accuracy of blood oxygen level-dependent (BOLD) cardiac magnetic resonance imaging (CMR) in comparison to invasively measured fractional flow reserve (FFR) which served as gold standard for a hemodynamic significant coronary lesion. METHODS AND RESULTS: -BOLD image was performed at rest and during adenosine infusion in a 1.5T CMR scanner. Thirty-six patients were analyzed for relative BOLD signal intensity increase according to the 16-segment model. Invasive FFR measurements were performed in the major three coronary arteries during adenosine infusion in all patients. A FFR ≤0.8 was regarded to indicate a significant coronary lesion. Relative BOLD signal intensity increase was significantly lower in myocardial segments supplied by coronary arteries with a FFR ≤0.8 compared to segments with a FFR >0.8 (1.1 ± 0.2 vs. 1.5 ± 0.2, p<0.0001). Sensitivity and specificity yielded 88.2% and 89.5%, respectively. CONCLUSIONS: -CMR BOLD imaging reliably detects hemodynamic significant CAD and is thus an alternative to contrast-enhanced perfusion studies.
Authors:
Thomas Walcher; Robert Manzke; Vinzenz Hombach; Wolfgang Rottbauer; Jochen Wöhrle; Peter Bernhardt
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-1
Journal Detail:
Title:  Circulation. Cardiovascular imaging     Volume:  -     ISSN:  1942-0080     ISO Abbreviation:  Circ Cardiovasc Imaging     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101479935     Medline TA:  Circ Cardiovasc Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 University of Ulm, Ulm, Germany;
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