Document Detail

Myocardial Perfusion Abnormalities by Intravenous Administration of the Contrast Agent NC100100 in an Experimental Model of Coronary Artery Thrombosis and Reperfusion.
MedLine Citation:
PMID:  11175105     Owner:  NLM     Status:  Publisher    
The aim of this study was to evaluate a second-generation echo contrast agent (NC100100) for the study of myocardial perfusion. In eight anesthetized open-chest dogs, this agent was injected intravenously under baseline conditions, during acute coronary thrombosis, and after reperfusion, using both fundamental (FI) and harmonic (HI) imaging, both continuous and intermittent imaging, and both ultrasound (US) and integrated backscatter (IBS) imaging. Contrast injections did not modify the hemodynamic parameters. With all imaging modalities, myocardial contrast enhancement (MCE) was higher with intermittent than with continuous imaging (134 vs 82 gray level/pixel using FI, P = 0.02; 62 vs 32 acoustic units using US HI, P = 0.02; and 52 vs 12 dB using IBS, P = 0.05). MCE equally increased using either US or IBS imaging. The accuracy of MCE in detecting perfusion defects during coronary occlusion and myocardial reperfusion after thrombolysis was very good (sensitivity and specificity = 93% and 95% and 89% and 93%, respectively). The extent of myocardial perfusion defects by echo contrast showed a closer correlation with microspheres using HI (r = 0.82) than FI (r = 0.53). Thus, the intravenous administration of NC100100 during intermittent HI allows myocardial perfusion abnormalities to be accurately detected during acute myocardial infarction.
Daniele Rovai; Birgitta Janerot-Sjöberg; András Nagy; Cecilia Marini; Silvia Burchielli; Michele Castellari; Maria-Aurora Morales; M. Giovanna Trivella; Jonny Ostensen; Alessandro Distante; Antonio L'Abbate
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Publication Detail:
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  15     ISSN:  1540-8175     ISO Abbreviation:  Echocardiography     Publication Date:  1998 Nov 
Date Detail:
Created Date:  2001-Feb-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  -    
Other Details:
Languages:  ENG     Pagination:  731-740     Citation Subset:  -    
CNR, Clinical Physiology Institute, via Savi, 8, 56126 Pisa, Italy.
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