Document Detail


Myocardial oxygen consumption change predicts left ventricular relaxation improvement in obese humans after weight loss.
MedLine Citation:
PMID:  21738241     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obesity adversely affects myocardial metabolism, efficiency, and diastolic function. Our objective was to determine whether weight loss can ameliorate obesity-related myocardial metabolism and efficiency derangements and that these improvements directly relate to improved diastolic function in humans. We studied 30 obese (BMI >30 kg/m2) subjects with positron emission tomography (PET) (myocardial metabolism, blood flow) and echocardiography (structure, function) before and after marked weight loss from gastric bypass surgery (N = 10) or moderate weight loss from diet (N = 20). Baseline BMI, insulin resistance, hemodynamics, left ventricular (LV) mass, systolic function, myocardial oxygen consumption (MVO2), and fatty acid (FA) metabolism were similar between the groups. MVO2/g decreased after diet-induced weight loss (P = 0.009). Total MVO2 decreased after dietary (P = 0.02) and surgical weight loss (P = 0.0006) and was related to decreased BMI (P = 0.006). Total myocardial FA utilization decreased (P = 0.03), and FA oxidation trended lower (P = 0.06) only after surgery. FA esterification and LV efficiency were unchanged. After surgical weight loss, LV mass decreased by 23% (Doppler-derived) E/E' by 33%, and relaxation increased (improved) by 28%. Improved LV relaxation related significantly to decreased BMI, insulin resistance, total MVO2, and LV mass but not FA utilization. Decreased total MVO(2) predicted LV relaxation improvement independent of BMI change (P = 0.02). Weight loss can ameliorate the obesity-related derangements in myocardial metabolism and LV structure and diastolic function. Decreased total MVO2 independently predicted improved LV relaxation, suggesting that myocardial oxygen metabolism may be mechanistically important in determining cardiac relaxation.
Authors:
C Huie Lin; Suraj Kurup; Pilar Herrero; Kenneth B Schechtman; J Christopher Eagon; Samuel Klein; Víctor G Dávila-Román; Richard I Stein; Gerald W Dorn; Robert J Gropler; Alan D Waggoner; Linda R Peterson
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-07-07
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  19     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-29     Completed Date:  2012-05-07     Revised Date:  2014-09-01    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1804-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Mass Index
Combined Modality Therapy
Diet, Reducing
Echocardiography, Doppler
Female
Gastric Bypass
Humans
Insulin Resistance
Male
Middle Aged
Muscle Relaxation*
Myocardium / metabolism*
Obesity / diet therapy,  metabolism*,  physiopathology*
Obesity, Morbid / diet therapy,  metabolism,  physiopathology,  surgery
Oxygen Consumption*
Positron-Emission Tomography
Ventricular Dysfunction, Left / etiology,  prevention & control
Ventricular Function, Left*
Weight Loss*
Grant Support
ID/Acronym/Agency:
5 P60 DK020579/DK/NIDDK NIH HHS; DK 56341/DK/NIDDK NIH HHS; P30 DK020579/DK/NIDDK NIH HHS; R01 HL073120-05/HL/NHLBI NIH HHS; R01-HL073120/HL/NHLBI NIH HHS; UL1 RR024992/RR/NCRR NIH HHS; UL1 RR024992/RR/NCRR NIH HHS
Comments/Corrections

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