| Myocardial Mononuclear Cell Infiltrates Are Not Associated with Increased Serum Cardiac Troponin I in Cynomolgus Monkeys. | |
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MedLine Citation:
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PMID: 22298795 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Myocardial mononuclear cell infiltrate is a spontaneous cardiac finding commonly identified in laboratory cynomolgus monkeys. The infiltrates are predominantly composed of macrophages with lesser lymphocytes and are not typically associated with histologically detectable cardiomyocyte degeneration. These infiltrates are of concern because they confound interpretation of test article-related histopathology findings in nonclinical safety toxicology studies. The interpretation of safety studies would be simplified by a biomarker that could identify myocardial infiltrates prior to animal placement on study. We hypothesized that monkeys with myocardial mononuclear cell infiltrates could be identified before necropsy using an ultrasensitive immunoassay for cardiac troponin I (cTnI). Serum cTnI concentrations in monkeys with myocardial infiltrates were not higher than those in monkeys without infiltrates at any of the sampling times before and on the day of necropsy. Increased serum cTnI levels are not suitable for screening monkeys with myocardial mononuclear cell infiltrates before placement in the study. |
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Authors:
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Michael E Dunn; Denise Coluccio; Tanja S Zabka; Gopakumar Gopalakrishnan; Gerard Hirkaler; Wanping Geng; Rosemary Nicklaus; Steven E Lipshultz; Lucette Doessegger; Brett H Saladino; Thomas Singer; Igor Mikaelian |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-31 |
Journal Detail:
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Title: Toxicologic pathology Volume: - ISSN: 1533-1601 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-2-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905907 Medline TA: Toxicol Pathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Non-Clinical Safety, Hoffmann-La Roche, Inc., Nutley, New Jersey, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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