Document Detail


Myocardial L-carnitine deficiency in a family of dogs with dilated cardiomyopathy.
MedLine Citation:
PMID:  2019534     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dilated cardiomyopathy in a family of dogs was found to be associated with decreased myocardial L-carnitine concentrations, when compared with those in control dogs. In 2 affected dogs, treatment with high doses of L-carnitine was associated with increased myocardial L-carnitine concentration and greatly improved health and myocardial function. Withdrawal of L-carnitine supplementation from these dogs resulted in development of myocardial dysfunction and clinical signs of dilated cardiomyopathy.
Authors:
B W Keene; D P Panciera; C E Atkins; V Regitz; M J Schmidt; A L Shug
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Veterinary Medical Association     Volume:  198     ISSN:  0003-1488     ISO Abbreviation:  J. Am. Vet. Med. Assoc.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-05-29     Completed Date:  1991-05-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503067     Medline TA:  J Am Vet Med Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  647-50     Citation Subset:  IM    
Affiliation:
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomyopathy, Dilated / drug therapy,  etiology,  genetics,  veterinary*
Carnitine / deficiency*,  therapeutic use
Dog Diseases / drug therapy,  etiology*,  genetics
Dogs
Echocardiography / veterinary
Male
Chemical
Reg. No./Substance:
541-15-1/Carnitine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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