Document Detail


Myocardial iron loading in patients with thalassemia major in Turkey and the potential role of splenectomy in myocardial siderosis.
MedLine Citation:
PMID:  21364469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iron-induced cardiac disease is the leading cause of death in thalassemia major (TM). Splenectomy is performed in TM to reduce transfusion requirements and iron intake. Prevalence of myocardial siderosis and its relationship with splenectomy in 146 patients with TM were investigated. The patients with myocardial siderosis (T2*<20 ms) accounted for 42% of the cohort. Splenectomized patients had a higher incidence of myocardial siderosis (48%) compared with those having intact spleen (28%) and significantly higher myocardial iron content. Higher myocardial iron content in splenectomized patients may deserve special attention for the role of spleen in iron regulation.
Authors:
Yesim Aydinok; Selen Bayraktaroglu; Dilek Yildiz; Hudaver Alper
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  33     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-22     Completed Date:  2011-09-01     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  374-8     Citation Subset:  IM    
Affiliation:
Department of Pediatric Hematology, Ege University Faculty of Medicine, Izmir, Turkey. yesim.aydinok@ege.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Ferritins / blood
Humans
Iron / metabolism
Middle Aged
Myocardium / metabolism,  pathology*
Prevalence
Siderosis / epidemiology*,  pathology*
Splenectomy / adverse effects,  statistics & numerical data*
Turkey / epidemiology
Young Adult
beta-Thalassemia* / epidemiology,  pathology,  surgery
Chemical
Reg. No./Substance:
7439-89-6/Iron; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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