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Myocardial Involvement During Ischemia-Induced Acute Liver Failure in the Pig.
MedLine Citation:
PMID:  23273174     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT Objective: The objective of this experimental study was to investigate a possible myocardial involvement in acute liver failure. Materials and Methods: A porcine model of acute liver failure induced by hepatic devascularization was used. Twenty animals were allocated to the Acute Liver Failure (ALF) or Control Group (CG). Serum cardiac troponin I (cTnI), MB isoenzyme of creatine kinase (CK-MB), and also hemodynamic variables were measured and compared before surgery (T(1)), at 4 hr (T(2)), and at 7 hr (T(3)) after the end of surgery. Results: Data from 10 pigs in the ALF and 7 in the CG were analyzed. In the ALF group, cTnI increased from 0.3 ± 0.055 to 0.35 ± 0.696 and 0.39 ± 0.06 ng/ml at T(1), T(2), and T(3) time points, respectively (p < .001). In the CG, cTnI was not significantly changed from 0.29 ± 0.07, to 0.31 ± 0.01, and 0.31 ± 0.11 ng/ml at T(1), T(2), and T(3) time points, respectively (p = .895). A statistically significant difference was found in cTnI between the groups at T(3) (z = -2.93, p = .002). CK-MB increased significantly in both groups: in ALF group, CK-MB changed from 3.43 ± 0.53 to 4.33 ± 0.73 and 7.14 ± 1.12 ng/ml at T(1), T(2), and T(3) time points, respectively (p < .001). In the CG, CK-MB changed from 3.6 ± 0.597 to 4.6 ± 1.07 and 6.2 ± 1.17 ng/ml at T(1), T(2), and T(3) time points, respectively, (p = .001). Mean arterial pressure (MAP) was significantly reduced in the ALF group. Conclusions: In a porcine model of acute liver failure, a significant increase of cTnI serum levels was found, indicating that a subclinical myocardial damage may occur as a result of heart involvement in the multiple organ dysfunction.
Authors:
Athanasia Tsaroucha; Constantinos Chondrogiannis; Alexia Mani; Chryssoula Staikou
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-28
Journal Detail:
Title:  Journal of investigative surgery : the official journal of the Academy of Surgical Research     Volume:  -     ISSN:  1521-0553     ISO Abbreviation:  J Invest Surg     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809255     Medline TA:  J Invest Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Anesthesiology, Aretaieio Hospital , Athens , Greece.
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